1-[4-(2-甲氧基乙氧基)苯基]哌嗪合成路线 （共 4 条）
反应条件
hydrogenchloride
T=80°C;
参考文献
Silverman, Lisa S.; Caldwell, John P.; Greenlee, William J.; Kiselgof, Eugenia; Matasi, Julius J.; Tulshian, Deen B.; Arik, Leyla; Foster, Carolyn; Bertorelli, Rosalia; Monopoli, Angela; Ongini, Ennio
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1659 - 1662
反应条件
palladium diacetate; Pd(tBu)3; sodium t-butanolate in toluene
参考文献
Matasi, Julius J.; Caldwell, John P.; Zhang, Hongtao; Fawzi, Ahmad; Cohen-Williams, Mary E.; Varty, Geoffrey B.; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3670 - 3674
反应条件
1: 80 percent / NaH / dimethylformamide / 60 °C
2: 95 percent / aq. HCl / 80 °C
View Scheme
参考文献
Silverman, Lisa S.; Caldwell, John P.; Greenlee, William J.; Kiselgof, Eugenia; Matasi, Julius J.; Tulshian, Deen B.; Arik, Leyla; Foster, Carolyn; Bertorelli, Rosalia; Monopoli, Angela; Ongini, Ennio
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1659 - 1662
反应条件
1: 80 percent / K2CO3 / acetone
2: Pd(OAc)2; tBuONa; Pd(tBu)3 / toluene
View Scheme
参考文献
Matasi, Julius J.; Caldwell, John P.; Zhang, Hongtao; Fawzi, Ahmad; Cohen-Williams, Mary E.; Varty, Geoffrey B.; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3670 - 3674
