1-苄基-5-氧-3-吡咯烷羧酸甲酯合成路线 （共 43 条）
反应条件
1.1: 28 percent / α-chymotrypsine (α-CT) / aq. phosphate buffer / 20 °C / pH 7.4 / low conversion 2.1: BH3-THF / tetrahydrofuran / -10 - 20 °C 2.2: aq. HCl / tetrahydrofuran; methanol / 1 h / Heating View Scheme
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
1: With dimethylsulfide; borane in toluene T=0 - 110°C; 16 h; Heating / reflux; 2: With sodium hydrogencarbonate in water; toluene T=-10 - 20°C; 2 h; Heating / reflux;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/18708 A2, 2006 ;
Location in patent: Page/Page column 21-22 ;
WO 2006/018708 A2
反应条件
hydrogenchloride; sodium hydroxide; ammonium formate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide in tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US6329380 B1, 2001 ;
US 6329380 B1
参考文献
Chinn, Jason P.; Choi, Seok-Ki; Fatheree, Paul R.; Marquess, Daniel; Turner, S. Derek
Patent: US2003/27822 A1, 2003 ;
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 50 °C 2: 10 palladium on activated charcoal; hydrogen / methanol / 48 h View Scheme
参考文献
Rodriguez-Lucena, David; Morin, Marie S.T.; Compain, Philippe
Letters in Organic Chemistry, 2011 , vol. 8, # 3 p. 155 - 162
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 50 °C 2: 10 palladium on activated charcoal; hydrogen / methanol / 48 h View Scheme
参考文献
Rodriguez-Lucena, David; Morin, Marie S.T.; Compain, Philippe
Letters in Organic Chemistry, 2011 , vol. 8, # 3 p. 155 - 162
反应条件
1: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating 2: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate 3: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 50 °C 2: 10 palladium on activated charcoal; hydrogen / methanol / 48 h View Scheme
参考文献
Rodriguez-Lucena, David; Morin, Marie S.T.; Compain, Philippe
Letters in Organic Chemistry, 2011 , vol. 8, # 3 p. 155 - 162
反应条件
1: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating 2: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate View Scheme
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
1: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating 2: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate 3: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
