1-苄基-5-氧-3-吡咯烷羧酸甲酯合成路线 （共 43 条）
反应条件
9-borabicyclo[3.3.1]nonane dimer in tetrahydrofuran T=65°C; 1 h;
参考文献
Collins, Christopher J.; Lanz, Marc; Singaram, Bakthan
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3673 - 3676
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran; dichloromethane
参考文献
Pfizer Inc.
Patent: US2003/187254 A1, 2003 ;
反应条件
1: 72 percent / aq. NH4OH / 12 h 2: 75 percent / PhI(OAc)2 / H2O; acetonitrile / 1 h / 20 °C 3: 80 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Jean, Ludovic; Baglin, Isabelle; Rouden, Jacques; Maddaluno, Jacques; Lasne, Marie-Claire
Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5645 - 5649
反应条件
ammonium hydroxide 12 h;
参考文献
Jean, Ludovic; Baglin, Isabelle; Rouden, Jacques; Maddaluno, Jacques; Lasne, Marie-Claire
Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5645 - 5649
反应条件
1: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating
2: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate
3: 85 percent / 2N NaOH / methanol / 20 °C
View Scheme
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
lithium borohydride in tetrahydrofuran
T=20°C; Inert atmosphere;
参考文献
Trippier, Paul C.; Benmohammed, Radhia; Kirsch, Donald R.; Silverman, Richard B.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6647 - 6650
反应条件
α-chymotrypsine (α-CT) in phosphate buffer
T=20°C; pH=7.4; high conversion;
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
α-chymotrypsine (α-CT) in phosphate buffer
T=20°C; pH=7.4; low conversion;
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
α-chymotrypsine (α-CT) in phosphate buffer
T=20°C; pH=7.4; high conversion;
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
α-chymotrypsine (α-CT) in phosphate buffer
T=20°C; pH=7.4; low conversion;
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
