2-氯-5-(甲硫基)苯甲酸合成路线 （共 4 条）
反应条件
in 1-methyl-pyrrolidin-2-one T=160°C; 72 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/67462 A1, 2006 ;
Location in patent: Page/Page column 61 ;
WO 2006/067462 A1
反应条件
1: With diphenyl phosphoryl azide; triethylamine in tert-butyl alcohol 6 h; Heating; 2: With hydrogenchloride in tetrahydrofuran 6 h; Heating;
参考文献
Padmanabhan, Seetharamaiyer; Perlman, Michael E; Zhang, Lu; Moore, Deke; Zhou, Dan; Fischer, James B; Durant, Graham J; McBurney, Robert N
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 501 - 504
反应条件
1: With sodium hydroxide; sodium hydrogencarbonate in water; acetone
T=20°C; 0.0833333 h;
2: With Oxonereg; in water; acetone
1 h;
3: With hydrogenchloride in water; acetone
参考文献
BIOLIPOX AB
Patent: WO2007/42816 A1, 2007 ;
Location in patent: Page/Page column 36 ;
WO 2007/042816 A1
参考文献
Sanofi Winthrop Inc.
Patent: US5488055 A1, 1996 ;
