1,4-二碘-2,5-二甲氧基苯合成路线 （共 24 条）
反应条件
1: 75 percent / boron tribromide / CH2Cl2 / 40 h / 20 °C 2: potassium hydroxide / dimethylsulfoxide / 20 °C View Scheme
参考文献
Liu, Yao; Jiang, Shujun; Schanze, Kirk S.
Chemical Communications, 2003 , # 5 p. 650 - 651
反应条件
1: boron tribromide / dichloromethane / 20 °C / |Inert atmosphere; |Schlenk technique 2: potassium hydroxide / acetone; dimethyl sulfoxide / 24 h / |Reflux; |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Pasquini, Chiara; Coniglio, Alessandra; Bassetti, Mauro
Tetrahedron Letters, 2012 , vol. 53, # 46 p. 6191 - 6194,4
反应条件
1: 99 percent / Na2CO3 / Pd(PPh3)4 / toluene; ethanol; H2O / 96 h / 80 °C 2: 91 percent / BBr3 / CH2Cl2 / 8 h / 0 °C 3: 71 percent / 2-di-tert-butylphosphino-2'-methylbiphenyl; KOAc; 2,6-di-tert-butyl-4-methylphenol / Pd(OAc)2 / toluene; 1,2-dimethoxy-ethane / 96 h / 100 °C View Scheme
参考文献
Kawaguchi, Keiko; Nakano, Koji; Nozaki, Kyoko
Journal of Organic Chemistry, 2007 , vol. 72, # 14 p. 5119 - 5128
反应条件
n-butyllithium 1.) ether, hexane, 10 min, 2.) ether, hexane, a) RT, 10 min, b) reflux, 10 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sargent, Thornton; Shulgin, Alexander T.; Mathis, Chester A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1071 - 1077
反应条件
boron tribromide in dichloromethane T=-78 - 20°C; 5 h;
参考文献
UNIVERSITA' DEGLI STUDI DI BARI; CONSIGLIO NAZIONALE DELLE RICERCHE; UNIVERSITA'DEGLI STUDI DEL SALENTO
Patent: WO2008/96239 A1, 2008 ;
Location in patent: Page/Page column 29 ;
反应条件
boron tribromide in dichloromethane T=20°C; Inert atmosphereCooling with acetone-dry ice;
参考文献
Pasquini, Chiara; Coniglio, Alessandra; Bassetti, Mauro
Tetrahedron Letters, 2012 , vol. 53, # 46 p. 6191 - 6194,4
反应条件
1: diisopropylamine; PPh3 / Pd(OAc)2; CuI / tetrahydrofuran / 1 h / Heating
2: 86 percent / Bu4NF / tetrahydrofuran / 0.08 h / 20 °C
View Scheme
参考文献
Shvartsberg, M. S.; Moroz, A. A.; Kiseleva, O. D.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 4 p. 608 - 611
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 4 p. 827 - 830
反应条件
1: 68 percent / boron tribromide / CH2Cl2 / 16 h / 20 °C
2: 76 percent / K2CO3 / acetone / 48 h / Heating
3: CuI; i-Pr2NH / [PdCl2(PPh3)2] / tetrahydrofuran; various solvent(s) / 20 °C
4: 275 mg / Bu4NF / tetrahydrofuran / 0.17 h / 20 °C
View Scheme
参考文献
Kim, Ik-Bum; Erdogan, Belma; Wilson, James N.; Bunz, Uwe H. F.
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6247 - 6254
反应条件
1: I2DMB With n-butyllithium in diethyl ether; hexane
T=-10 - -5°C; 1.33333 h;
2: N,N-dimethyl-formamide in diethyl ether; hexane
T=20°C; 6 h;
参考文献
Ko, Soo-Byung; Cho, An-Na; Kim, Mi-Jeong; Lee, Chang-Ryul; Park, Nam-Gyu
Dyes and Pigments, 2012 , vol. 94, # 1 p. 88 - 98
反应条件
n-butyllithium
1.) ether, hexane, 10 min, 2.) ether, hexane, a) RT, 10 min, b) reflux, 10 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sargent, Thornton; Shulgin, Alexander T.; Mathis, Chester A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1071 - 1077
