(R)-(−)-环氧氯丙烷合成路线 (共 62 条)
反应条件
boron trifluoride diethyl etherate T=0 - 40°C;
参考文献
Babu, K. Chandra; Vysabhattar, Raman; Srinivas; Nigam, Satish; Madhusudhan; Mukkanti
Tetrahedron Asymmetry, 2010 , vol. 21, # 21-22 p. 2619 - 2624
反应条件
potassium fluoride on basic alumina in 2-methyl tetrahydrofuran 3 h; Inert atmosphereReflux; stereospecific reaction;
参考文献
Pace, Vittorio; Hoyos, Pilar; Fernandez, Maria; Sinisterra, Jose V.; Alcantara, Andres R.
Green Chemistry, 2010 , vol. 12, # 8 p. 1380 - 1382
反应条件
potassium carbonate in ipa T=80 - 90°C; 5 h; Heating / reflux;
参考文献
ORCHID RESEARCH LABORATORIES, LTD.
Patent: US2007/111998 A1, 2007 ;
Location in patent: Page/Page column 16 ;
反应条件
caesium carbonate in acetonitrile Reflux;
参考文献
Sun, Dianqing; Scherman, Michael S.; Jones, Victoria; Hurdle, Julian G.; Woolhiser, Lisa K.; Knudson, Susan E.; Lenaerts, Anne J.; Slayden, Richard A.; McNeil, Michael R.; Lee, Richard E.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3588 - 3594
反应条件
tetra-(n-butyl)ammonium iodide; caesium carbonate in acetonitrile T=100 - 105°C; 5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/106295 A2, 2004 ;
Location in patent: Page 27 ;
反应条件
boron trifluoride diethyl etherate in 1,2-dichloro-ethane T=45°C; 2 h;
参考文献
Rotstein, David Mark; Melville, Chris Richard
Patent: US2008/249087 A1, 2008 ;
Location in patent: Page/Page column 35 ;
US 20080249087 A1
反应条件
1: With N-benzyl-N,N,N-trimethyl-ammonium chloride in isopropyl alcohol T=40°C; 24 h; 2: With potassium tert-butylate in isopropyl alcohol T=20°C; 3 h;
参考文献
Miki, Yasushi; Mikami, Masafumi
Patent: US2006/19993 A1, 2006 ;
Location in patent: Page/Page column 5 ;
反应条件
N-benzyl-N,N,N-trimethyl-ammonium chloride in DMF (N,N-dimethyl-formamide) T=20°C; 16 h;
参考文献
DAISO CO., LTD.
Patent: EP1403267 A1, 2004 ;
Location in patent: Page 6 ;
反应条件
chloro-trimethyl-silane
参考文献
Kaupmann, Klemens; Bettler, Bernhard; Bittiger, Helmut; Frostl, Wolfgang; Mickel, Stuart J.
Patent: US2002/91250 A1, 2002 ;
US 20020091250 A1
反应条件
sodium hydroxide; N-benzyl-N,N,N-trimethyl-ammonium chloride 1.) 5 deg C, 20 h, 2.) RT, 12 h; Yield given. Multistep reaction;
参考文献
Kitaori, Kazuhiro; Takehira, Yosikazu; Furukawa, Yoshiro; Yoshimoto, Hiroshi; Otera, Junzo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 3 p. 505 - 507