(R)-(−)-环氧氯丙烷合成路线 （共 62 条）
反应条件
sodium citrate buffer; Agrobacterium radiobacter AD1 haloalcohol dehalogenase; sodium chloride T=22°C; pH=5.5; Product distribution; Further Variations:pH-values;
参考文献
Elenkov, Maja Majeric; Tang, Lixia; Meetsma, Auke; Hauer, Bernhard; Janssen, Dick B.
Organic Letters, 2008 , vol. 10, # 12 p. 2417 - 2420
反应条件
caesium carbonate in acetonitrile Reflux;
参考文献
Sun, Dianqing; Scherman, Michael S.; Jones, Victoria; Hurdle, Julian G.; Woolhiser, Lisa K.; Knudson, Susan E.; Lenaerts, Anne J.; Slayden, Richard A.; McNeil, Michael R.; Lee, Richard E.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3588 - 3594
反应条件
tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide in water T=20 - 100°C; 1 h;
参考文献
PIRAMAL HEALTHCARE LIMITED; MASCARENHAS, Malcolm; PATIL, Shashikant; JANRAO, Ravindra Ashok; ROYCHOWDHURY, Abhijit
Patent: WO2012/143874 A1, 2012 ;
Location in patent: Page/Page column 35 ;
反应条件
sodium hydroxide; boron trifluoride diethyl etherate 1.) 50 deg C, 18 h, 2.) ether, RT, 18 h; Yield given. Multistep reaction;
参考文献
Takano, Seiichi; Sekiguchi, Yoshinori; Setoh, Masaki; Yoshimitsu, Takehiko; Inomata, Kohei; et al.
Heterocycles, 1990 , vol. 31, # 9 p. 1715 - 1719
反应条件
caesium carbonate in acetonitrile Reflux;
参考文献
Sun, Dianqing; Scherman, Michael S.; Jones, Victoria; Hurdle, Julian G.; Woolhiser, Lisa K.; Knudson, Susan E.; Lenaerts, Anne J.; Slayden, Richard A.; McNeil, Michael R.; Lee, Richard E.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3588 - 3594
反应条件
boron trifluoride diethyl etherate in dichloromethane
参考文献
Jin, Cheng-Zhe; Nagasawa, Hideko; Shimamura, Mariko; Uto, Yoshihiro; Inayama, Seiichi; Takeuchi, Yoshio; Kirk, Kenneth L.; Hori, Hitoshi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4917 - 4927
反应条件
potassium carbonate in acetonitrile 14 h; Reflux; optical yield given as percent ee;
参考文献
Pujala, Brahmam; Rana, Shivani; Chakraborti, Asit K.
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8768 - 8780
反应条件
1: (R)-(-)-epichlorohydrin; α-naphthol With potassium carbonate in acetonitrile Heating; 2: N-(2-methoxyphenyl)-piperazine T=80°C; 0.166667 h; Further stages. Title compound not separated from byproducts.;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
1: (R)-(-)-epichlorohydrin; α-naphthol With potassium carbonate in acetonitrile Heating; 2: N-(2-methoxyphenyl)-piperazine T=80°C; 0.166667 h; Further stages. Title compound not separated from byproducts.;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in N-methyl-acetamide
