(R)-(−)-环氧氯丙烷合成路线 （共 62 条）
反应条件
sodium hydroxide in N-methyl-acetamide
反应条件
caesium carbonate in water; acetonitrile
参考文献
AstraZeneca AB
Patent: US6559143 B1, 2003 ;
US 6559143 B1
反应条件
1: With pyridine in acetone T=40°C; 48 h; 2: With sodium hydroxide in methanol; water T=0°C; 4 h; Product distribution / selectivity;
参考文献
AHN-GOOK PHARMACEUTICAL CO., LTD.; RSTECH CORPORATION
Patent: WO2008/16199 A1, 2008 ;
Location in patent: Page/Page column 9 ;
反应条件
potassium carbonate in acetonitrile 14 h; Reflux; optical yield given as percent ee;
参考文献
Pujala, Brahmam; Rana, Shivani; Chakraborti, Asit K.
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8768 - 8780
反应条件
N-benzyl-N,N,N-trimethyl-ammonium chloride in isopropyl alcohol T=10°C; 46 h;
参考文献
EP1403267 A1, ;
Page 5 ;
反应条件
N-benzyl-N,N,N-trimethyl-ammonium chloride in isopropyl alcohol T=40°C; 22 h;
参考文献
EP1403267 A1, ;
Page 6-7 ;
反应条件
N-benzyl-N,N,N-trimethyl-ammonium chloride in DMF (N,N-dimethyl-formamide) T=20°C; 16 h;
参考文献
EP1403267 A1, ;
Page 6 ;
反应条件
potassium fluoride on basic alumina in 2-methyl tetrahydrofuran 3 h; Inert atmosphereReflux; stereospecific reaction;
参考文献
Green Chemistry, , vol. 12, # 8 p. 1380 - 1382
反应条件
1: T=-78 - 0°C; 2.5 h;
2: With sodium hydroxide in tetrahydrofuran
20 h;
参考文献
Dewi-Wuelfing, Purnama; Gebauer, Julian; Blechert, Siegfried
Synlett, 2006 , # 3 p. 487 - 489
反应条件
copper(l) iodide in diethyl ether
T=-78°C;
参考文献
Sakaguchi, Kazuhiko; Kitamura, Tohru; Shiomi, Yutaka; Koden, Mitsuhiro; Kuratate, Tomoaki
Chemistry Letters, 1991 , # 8 p. 1383 - 1386
