4-甲基-5-咪唑甲酸乙酯合成路线 （共 17 条）
反应条件
potassium carbonate in acetonitrile Reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157273 A1, 2008 ;
Location in patent: Page/Page column 86 ;
反应条件
sodium hydride 1.) THF, 2.) overnight; Yield given. Multistep reaction;
参考文献
Ohno; Adachi; Koumori; Mizukoshi; Nagasaka; Ichihara; Kato -
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1463 - 1473
参考文献
Richmond, Ann; Yang, Jinming; Amiri, Katayoun; Dhawan, Punita
Patent: US2006/25419 A1, 2006 ;
Location in patent: Page/Page column 5 ;
反应条件
1: 4-methylimidazole-5-carboxylic acid ethyl ester With sodium hydride in tetrahydrofuran; mineral oil
T=20°C; Inert atmosphere;
2: methyl iodide in tetrahydrofuran; mineral oil
T=0 - 20°C; Inert atmosphere;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; DOLLINGER, Horst; GNAMM, Christian; FIEGEN, Dennis; HOFFMANN, Matthias; LAMB, David, James; KLICIC, Jasna; SCHNAPP, Andreas
Patent: WO2013/156608 A1, 2013 ;
Location in patent: Page/Page column 48 ;
反应条件
sodium hydride
1.) THF, 2.) overnight; Yield given. Multistep reaction;
参考文献
Ohno; Adachi; Koumori; Mizukoshi; Nagasaka; Ichihara; Kato -
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1463 - 1473
反应条件
sodium hydroxide; tetrabutylammomium bromide in toluene
T=20°C; 2 h;
参考文献
Sonegawa, Motoharu; Yokota, Masayuki; Tomiyama, Hiroshi; Tomiyama, Tsuyoshi
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 5 p. 706 - 710
反应条件
sodium hydride
1.) THF, RT, 2 h, 2.) THF, RT, overnight; Yield given. Multistep reaction;
参考文献
Davey
Journal of Organic Chemistry, 1987 , vol. 52, # 19 p. 4379 - 4381
