2-(3-甲基丁亚基)丙二酸二乙酯合成路线 （共 19 条）
反应条件
in ethanol T=25 - 35°C; 2 - 3 h;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2008/62460 A2, 2008 ;
Location in patent: Page/Page column 18-20 ;
反应条件
water; BnQN+Cl- in toluene T=20°C;
参考文献
PFIZER IRELAND PHARMACEUTICALS; DAVIES, Benjamin, Simon; GUZMAN, Mark, M.; MARTINEZ, Carlos, A.; McDAID, Paul, Oliver; O'NEILL, Padraig, Mary; SHANMUGAM, Elango
Patent: WO2010/70593 A2, 2010 ;
Location in patent: Page/Page column 28-32 ;
反应条件
in ethanol T=25 - 42°C; Product distribution / selectivity;
参考文献
PFIZER IRELAND PHARMACEUTICALS; DAVIES, Benjamin, Simon; GUZMAN, Mark, M.; MARTINEZ, Carlos, A.; McDAID, Paul, Oliver; O'NEILL, Padraig, Mary; SHANMUGAM, Elango
Patent: WO2010/70593 A2, 2010 ;
Location in patent: Page/Page column 28-32 ;
反应条件
potassium carbonate in ethanol T=20°C; 12 h;
参考文献
Wang, Jun; Li, Wei; Liu, Yanling; Chu, Yangyang; Lin, Lili; Liu, Xiaohua; Feng, Xiaoming
Organic Letters, 2010 , vol. 12, # 6 p. 1280 - 1283
反应条件
1: hydrogen 2: method of Krapcho 3: LiAlH4 4: conditions of Quirico and Fischli View Scheme
参考文献
Huffman, John W.; Liddle, John; Duncan Jr., Sammy G.; Yu, Shu; Martin, Billy R.; Wiley, Jenny L.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 12 p. 2383 - 2396
反应条件
pyridine; ethanol; trimethylphenylammonium hydroxide und Erwaermen des Reaktionsprodukts mit wss.HCl;
参考文献
Chimija chim.Technol.(NDVS)Chem.Abstr., , p. 545
Chimija chim.Technol.(NDVS)Chem.Abstr., , p. 2149
反应条件
1: 70 percent / NaH / tetrahydrofuran / a.) 0 deg C, 2 h, b.) room temperature, 3 h, c.) 40 deg C, 3 h 2: 17.20 g / LiAlH4 / diethyl ether / a.) 0 deg C, 30 min, b.) room temperature, 5.5 h 3: 72 percent / pyridine / 4 h / 0 °C 4: 80 percent / H2 / 10percent Pd-C / ethanol / Ambient temperature 5: H2O; propan-2-ol / pig pancreatic lipase, pH 7 buffer (K2HPO4-KH2PO4) View Scheme
参考文献
Guanti, Giuseppe; Banfi, Luca; Narisano, Enrica
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1540 - 1554
反应条件
1.1: n-dipropylamine / 16 h / 15 - 55 °C 2.1: hydrogen bromide / water / 72 h / 100 °C 3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 4.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 4.2: pH 2 View Scheme
反应条件
1.1: n-dipropylamine / 16 h / 15 - 55 °C 2.1: hydrogen bromide / water / 72 h / 100 °C 3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 4.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 4.2: pH 2 5.1: acetone / water / 80 °C 6.1: ammonia / water / 5 h / 80 °C 6.2: 0 °C / pH 1 View Scheme
反应条件
1: hydrogen 2: method of Krapcho 3: LiAlH4 View Scheme
参考文献
Huffman, John W.; Liddle, John; Duncan Jr., Sammy G.; Yu, Shu; Martin, Billy R.; Wiley, Jenny L.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 12 p. 2383 - 2396
