1: iso-butyronitrile With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; 0.333333 h;
2: 4-bromo-but-1-ene in tetrahydrofuran
T=-78 - 20°C;
参考文献
Burrell, Adam J. M.; Coldham, Iain; Watson, Luke; Oram, Niall; Pilgram, Christopher D.; Martin, Nathaniel G.
Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2290 - 2300
1: 4-bromo-but-1-ene With iodine; magnesium in tetrahydrofuran
Reflux;
2: (+/-)-2-Ethyloxirane With dilithium tetrachlorocuprate in tetrahydrofuran
T=-50°C; 1 h;
iodine; magnesium
1)diethylether, 2 h room temp.,2 h reflux 2)4 h reflux, 12 h room temp., poured on ice 3)barium hydroxide octahydrate, steam-distillation; Multistep reaction;
参考文献
Cervinka, Otakar; Fabryova, Anna; Josef, Jan; Sermek, Vladimir; Smrckova, Svatava
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 12 p. 3407 - 3412
