17-叠氮-3,6,9,12,15-五氧杂十七烷-1-胺合成路线 （共 8 条）
反应条件
hydrogenchloride; triphenylphosphine in diethyl ether; water T=20°C; 4 h;
参考文献
AMERSHAM HEALTH AS; GE HEALTHCARE LIMITED
Patent: WO2006/30291 A2, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
hydrazine in ethanol; water 2 h; Heating / reflux;
参考文献
GPC Biotech, Inc.
Patent: US7230101 B1, 2007 ;
Location in patent: Page/Page column 60; 78 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.5 h / 0 °C 2: sodium azide / N,N-dimethyl-formamide / 2.5 h / 110 °C 3: water; triphenylphosphine / N,N-dimethyl-formamide / 10 h / 20 °C View Scheme
参考文献
Goswami, Lalit N.; Houston, Zachary H.; Sarma, Saurav J.; Jalisatgi, Satish S.; Hawthorne, M. Frederick
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1116 - 1126
反应条件
1: sodium azide / N,N-dimethyl-formamide / 15 h / 65 °C 2: hydrogenchloride; triphenylphosphine / water; diethyl ether / 20 °C View Scheme
参考文献
Risseeuw, Martijn D. P.; DeClercq, Dries J. H.; Lievens, Sam; Hillaert, Ulrik; Sinnaeve, Davy; VandenBroeck, Freya; Martins, Jose C.; Tavernier, Jan; VanCalenbergh, Serge
ChemMedChem, 2013 , vol. 8, # 3 p. 521 - 526
反应条件
1: sodium azide / N,N-dimethyl-formamide / 2.5 h / 110 °C 2: water; triphenylphosphine / N,N-dimethyl-formamide / 10 h / 20 °C View Scheme
参考文献
Moldovan, Rares-Petru; Zoellinger, Michael; Jones, Peter G.; Kelter, Gerhard; Fiebig, Heinz-Herbert; Lindel, Thomas
European Journal of Organic Chemistry, 2012 , # 4 p. 685 - 698
反应条件
1: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C 2: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C 3: N,N-dimethyl-formamide / 15 h / 110 °C 4: hydrazine / ethanol / 3 h / 60 °C View Scheme
参考文献
Goswami, Lalit N.; Houston, Zachary H.; Sarma, Saurav J.; Jalisatgi, Satish S.; Hawthorne, M. Frederick
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1116 - 1126
反应条件
1: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C 2: N,N-dimethyl-formamide / 15 h / 110 °C 3: hydrazine / ethanol / 3 h / 60 °C View Scheme
参考文献
Goswami, Lalit N.; Houston, Zachary H.; Sarma, Saurav J.; Jalisatgi, Satish S.; Hawthorne, M. Frederick
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1116 - 1126
反应条件
1: N,N-dimethyl-formamide / 15 h / 110 °C 2: hydrazine / ethanol / 3 h / 60 °C View Scheme
参考文献
Goswami, Lalit N.; Houston, Zachary H.; Sarma, Saurav J.; Jalisatgi, Satish S.; Hawthorne, M. Frederick
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1116 - 1126
