5,5-二甲基-2-吡咯烷酮合成路线 （共 10 条）
反应条件
sodium tetrahydroborate; 0.5NiCl2*6H2O in methanol T=0 - 25°C; 48 h;
参考文献
Coyle, Jason P.; Kurek, Agnieszka; Pallister, Peter J.; Sirianni, Eric R.; Yap, Glenn P. A.; Barry, Sean T.
Chemical Communications, 2012 , vol. 48, # 84 p. 10440 - 10442
反应条件
di-tert-butyl peroxide in isopropylamine
参考文献
BASF Aktiengesellschaft
Patent: US4855444 A1, 1989 ;
反应条件
di-tert-butyl peroxide in methanol; isopropylamine
参考文献
BASF Aktiengesellschaft
Patent: US4855444 A1, 1989 ;
反应条件
trifluorormethanesulfonic acid in dichloromethane T=20°C; 2 h;
参考文献
Marson, Charles M.; Fallah, Asad
Tetrahedron Letters, 1994 , vol. 35, # 2 p. 293 - 296
参考文献
Buckley et al.
Journal of the Chemical Society, 1947 , p. 1507
参考文献
Schumann,E.L. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 464 - 477
反应条件
tetrahydrofuran; lithium aluminium tetrahydride
参考文献
Moffett
Org.Synth.Coll.Vol.IV, <1963>354
Full Text Show Details
Moffett; White
Journal of Organic Chemistry, 1952 , vol. 17, p. 407,412
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 16 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran T=0°C; 0.75 h; 3: With hydrogenchloride in tetrahydrofuran; diethyl ether
参考文献
AKZO NOBEL N.V.
Patent: WO2005/89754 A1, 2005 ;
Location in patent: Page/Page column 51-52 ;
WO 2005/089754 A1
反应条件
1: Cp2ZrHCl / tetrahydrofuran / 3 h / -20 - 20 °C
2: 1 h
3: aq. HCl / 12 h / Heating
View Scheme
参考文献
Xia, Qian; Ganem, Bruce
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1597 - 1598
反应条件
1: lithium alanate; tetrahydrofuran
2: 160 °C
View Scheme
参考文献
Moffett; White
Journal of Organic Chemistry, 1952 , vol. 17, p. 407,412
