N,N-二乙基-2-甲氧基苯甲酰胺合成路线 （共 33 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium; magnesium bromide in tetrahydrofuran; diethyl ether; cyclohexane
1.) -78 deg C, 45 min; 2.) r.t., 3 h;
参考文献
Wulff, William D.; Tang, Peng-Cho; Chan, Kin-Shing; McCallum, J. Stuart; Yang, Dominic C.; Gilbertson, Scott R.
Tetrahedron, 1985 , vol. 41, # 24 p. 5813 - 5832
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium
1) THF, -78 deg C, 1 h, 2) 20 min, -78 deg C, 3) room temperature, 2 h; Yield given. Multistep reaction;
参考文献
Mills, Robert J.; Taylor, Nicholas J.; Snieckus, Victor
Journal of Organic Chemistry, 1989 , vol. 54, # 18 p. 4372 - 4385
反应条件
1: 1.) sec-BuLi , TMEDA / THF , cyclohexane , 1.) -78 deg C , 1 h , 2.) -78 deg C to room temperature , 8 h
2: 1.) sec-BuLi
View Scheme
参考文献
Watanabe, Mitsuaki; Sahara, Masanori; Kubo, Masaki; Furukawa, Sunao; Billedeau, R. J.; Snieckus, V.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 742 - 747
反应条件
1: 1.) sec-BuLi , TMEDA / THF , cyclohexane , 1.) -78 deg C , 1 h , 2.) -78 deg C to room temperature , 8 h
2: 1.) sec-BuLi
3: 99 percent / NaBH4 / ethanol / 2 h
4: 82 percent / p-Toluenesulfonic acid / toluene / 8 h / Heating
View Scheme
参考文献
Watanabe, Mitsuaki; Sahara, Masanori; Kubo, Masaki; Furukawa, Sunao; Billedeau, R. J.; Snieckus, V.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 742 - 747
反应条件
Yield given. Multistep reaction;
参考文献
Sibi; Miah; Snieckus
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 737 - 742
反应条件
Yield given. Multistep reaction;
参考文献
Salvadori, Piero; Superchi, Stefano; Minutolo, Filippo
Journal of Organic Chemistry, 1996 , vol. 61, # 13 p. 4190 - 4191
反应条件
Yield given. Multistep reaction;
参考文献
Reed, J. N.; Snieckus, V.
Tetrahedron Letters, 1983 , vol. 24, # 36 p. 3795 - 3798
反应条件
1: BBr3 / CH2Cl2 / -78 °C
2: 6 h / 40 °C
View Scheme
参考文献
Billedeau, R.J.; Sibi, M.P.; Snieckus, V.
Tetrahedron Letters, 1983 , vol. 24, # 42 p. 4515 - 4518
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium
1.) ether, -78 deg C, 1 h, 2.) ether, -40 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Potts, Kevin T.; Bhattacharjee, Debkumar; Walsh, Eileen B.
Journal of Organic Chemistry, 1986 , vol. 51, # 11 p. 2011 - 2021
反应条件
1.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 1 h / -78 °C
1.2: tetrahydrofuran; cyclohexane / -78 - 20 °C
1.3: 97 percent / aq. HCl; NH4Cl / tetrahydrofuran; cyclohexane / pH 5 - 6
2.1: 85 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating
3.1: 92 percent / LDA / tetrahydrofuran / 3 h / 20 °C
4.1: 99 percent / O2; salcomine / dimethylformamide / 4 h / 20 °C
5.1: aq. KOH / 1 h / 90 °C
5.2: 96 percent / Pb(OAc)4 / benzene / 20 °C
View Scheme
参考文献
Fu, Jian-Min; Snieckus, Victor
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919
