N,N-二乙基-2-甲氧基苯甲酰胺合成路线 （共 33 条）
反应条件
1.1: sec.-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; cyclohexane / 2 h / -78 °C / |Inert atmosphere
1.2: -78 - 20 °C / |Inert atmosphere
2.1: hydrogenchloride; acetic acid; water / 12 h / |Reflux
View Scheme
参考文献
Mamidyala, Sreeman K.; Ramu, Soumya; Huang, Johnny X.; Robertson, Avril A.B.; Cooper, Matthew A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1667 - 1670
反应条件
diethyl ether; benzene
Behandeln des Reaktionsprodukts mit wss. HCl;
参考文献
Couturier
Annales de Chimie (Cachan, France), 1938 , vol. <11> 10, p. 559,597
反应条件
1: 2-methoxy-N,N-diethyl-benzamide With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran
T=-78°C; 0.5 h;
2: dimethyl-disulfide in tetrahydrofuran
T=-78 - 20°C; 4.25 h;
参考文献
Dittmann, Marc; Graupner, Franziska F.; Maerz, Benjamin; Oesterling, Sven; Devivie-Riedle, Regina; Zinth, Wolfgang; Engelhard, Martin; Luettke, Wolfgang
Angewandte Chemie - International Edition, 2014 , vol. 53, # 2 p. 591 - 594
Angew. Chem., 2013 , vol. 126, # 2 p. 602 - 605,4
反应条件
1.1: sec-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C
1.2: 72 percent / tetrahydrofuran; cyclohexane / -78 - 20 °C
2.1: 65 percent / LDA / tetrahydrofuran / -78 - 20 °C
3.1: 82 percent / NaBH4; NaOH / methanol; H2O / 13 h / Heating
View Scheme
参考文献
Mukherjee, Chandrani; De, Asish
Synlett, 2002 , # 2 p. 325 - 327
反应条件
1: ortho-methoxybenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=-10 - 20°C;
2: diethylamine in dichloromethane
T=0 - 20°C; 0.833333 h;
参考文献
Vamshikrishna; Srihari
Tetrahedron, 2012 , vol. 68, # 5 p. 1540 - 1546
反应条件
in dichloromethane
T=25°C; 1 h;
参考文献
Nicolas, Cyril; Bernardinelli, Gerald; Lacour, Jerome
Journal of Physical Organic Chemistry, 2010 , vol. 23, # 11 p. 1049 - 1056
反应条件
1: SOCl2 / toluene / 2 h / Heating
2: diethyl ether / 1 h
View Scheme
参考文献
Gibson, Jennifer S.; Andrey, Olivier; Brimble, Margaret A.
Synthesis, 2007 , # 17 p. 2611 - 2613
反应条件
bis-triphenylphosphine-palladium(II) chloride; cesium fluoride in tetrahydrofuran
T=80°C; 16 h;
参考文献
Lysen, Morten; Kelleher, Susan; Begtrup, Mikael; Kristensen, Jesper Langgaard
Journal of Organic Chemistry, 2005 , vol. 70, # 13 p. 5342 - 5343
反应条件
[Bmim][PdI2](PPh3); potassium carbonate in 1,4-dioxane
T=90°C; P=15001.5 Torr; 5 h; Autoclave; Reagent/catalyst;
参考文献
Zheng, Shuzhan; Wang, Yan; Zhang, Chunyan; Liu, Jianhua; Xia, Chungu
Applied Organometallic Chemistry, 2014 , vol. 28, # 1 p. 48 - 53
反应条件
Pd2(μ-I)2(PtBu3)2 in toluene
T=100°C; P=900.09 Torr; 12 h;
参考文献
Gong, Xiuqing; Miller, Philip W.; Gee, Antony D.; Long, Nicholas J.; De Mello, Andrew J.; Vilar, Ramon
Chemistry - A European Journal, 2012 , vol. 18, # 10 p. 2768 - 2772
