4-氯-吡啶并[3,2-d]嘧啶合成路线 （共 9 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; Reflux;
参考文献
Petric, Andrej; Tisler, M.; Stanovnik, Branko
Monatshefte fuer Chemie, 1983 , vol. 114, p. 615 - 624
反应条件
1: 73 percent / 90percent H2SO4 / 3.5 h / 70 °C 2: H2 / Pd/C / ethyl acetate; methanol / 144 h / 3102.9 Torr 3: 42 h 4: 86 percent / POCl3 / 4 h / Heating View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
1: H2 / Pd/C / ethyl acetate; methanol / 144 h / 3102.9 Torr 2: 42 h 3: 86 percent / POCl3 / 4 h / Heating View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
1: 3 h / 140 - 180 °C 2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Reflux View Scheme
参考文献
INFINITY PHARMACEUTICALS INC.; INTELLIKINE, LLC; CASTRO, Alfredo, C.; EVANS, Catherine, A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel, A.; TREMBLAY, Martin, R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina
Patent: WO2013/12915 A1, 2013 ;
WO 2013/012915 A1
反应条件
1: 42 h 2: 86 percent / POCl3 / 4 h / Heating View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
methanesulfonic acid; triethylamine; aniline in methanol; ethanol; chloroform; acetone
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
反应条件
triethylamine in chloroform
1.5 h; Heating;
参考文献
Petric, Andrej; Tisler, M.; Stanovnik, Branko
Monatshefte fuer Chemie, 1983 , vol. 114, p. 615 - 624
反应条件
1: NEt3 / CHCl3 / 1.5 h / Heating
2: conc. HCl / acetic acid / 1 h / Heating
View Scheme
参考文献
Petric, Andrej; Tisler, M.; Stanovnik, Branko
Monatshefte fuer Chemie, 1983 , vol. 114, p. 615 - 624
反应条件
hydrazine hydrate in ethanol
0.5 h; Heating;
参考文献
Petric, Andrej; Tisler, Miha; Stanovnik, Branko
Monatshefte fuer Chemie, 1985 , vol. 116, p. 1309 - 1320
