5-氯-2,4-二硝基甲苯合成路线 （共 22 条）
参考文献
Reverdin; Crepieux
Chemische Berichte, 1900 , vol. 33, p. 2505
参考文献
Corbett,J.F.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1972 , p. 999 - 1005
反应条件
1: 89 percent / Et3N / ethanol / 4 h / Heating 2: 65 percent / hydrazine hydrate / Raney-Ni / ethanol; 1,2-dichloro-ethane / 4 h / 60 °C 3: 78 percent / tetrakis(acetonitrile)copper(I) tetrafluoroborate / toluene / 20 h / 90 °C 4: 90 percent / H2 / Raney-Ni / ethanol; H2O / 1 h / 760 Torr / Ambient temperature View Scheme
参考文献
Knapp, Spencer; Ziv, Joseph; Rosen, Joseph D.
Tetrahedron, 1989 , vol. 45, # 5 p. 1293 - 1298
反应条件
sodium acetate
T=150°C;
参考文献
Cullinane; Embrey; Davies
Journal of the Chemical Society, 1932 , p. 3363
反应条件
1: 89 percent / Et3N / ethanol / 4 h / Heating
2: 65 percent / hydrazine hydrate / Raney-Ni / ethanol; 1,2-dichloro-ethane / 4 h / 60 °C
3: 78 percent / tetrakis(acetonitrile)copper(I) tetrafluoroborate / toluene / 20 h / 90 °C
4: 90 percent / H2 / Raney-Ni / ethanol; H2O / 1 h / 760 Torr / Ambient temperature
5: 85 percent / Ac2O / Ambient temperature
6: 82 percent / LiAlH4 / tetrahydrofuran / 3 h / 0 - 5 °C
View Scheme
参考文献
Knapp, Spencer; Ziv, Joseph; Rosen, Joseph D.
Tetrahedron, 1989 , vol. 45, # 5 p. 1293 - 1298
反应条件
hydrogenchloride; tin(ll) chloride
T=70 - 75°C; 1 h;
参考文献
Rogister, Francoise; Laeckmann, Didier; Plasman, Pierre-Olivier; Van Eylen, Francoise; Ghyoot, Marianne; Maggetto, Carine; Liegeois, Jean-Francois; Geczy, Joseph; Herchuelz, Andre; Delarge, Jacques; Masereel, Bernard
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 7-8 p. 597 - 614
参考文献
Reverdin; Crepieux
Chemische Berichte, 1900 , vol. 33, p. 2505
反应条件
acetamide; sodium acetate
T=180°C;
参考文献
Sane; Joshi
Journal of the Indian Chemical Society, 1928 , vol. 5, p. 300
Chem. Zentralbl., 1928 , vol. 99, # II p. 1432
Full Text Show Details
Borsche
Chemische Berichte, 1917 , vol. 50, p. 1354
反应条件
1: KOH
2: H2 / Pd-C
View Scheme
参考文献
Corbett,J.F.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1972 , p. 999 - 1005
反应条件
ethanol; ammonia
T=100°C;
参考文献
Borsche; Fiedler
Chemische Berichte, 1913 , vol. 46, p. 2125
