5-苯基异噁唑-3-甲酸甲酯合成路线 （共 19 条）
反应条件
silver tetrafluoroborate; phenol in tetrahydrofuran 12 h; Reflux;
参考文献
Ueda, Masafumi; Ikeda, Yuki; Sato, Aoi; Ito, Yuta; Kakiuchi, Maiko; Shono, Hiroko; Miyoshi, Tetsuya; Naito, Takeaki; Miyata, Okiko
Tetrahedron, 2011 , vol. 67, # 25 p. 4612 - 4615
反应条件
hydroxylamine hydrochloride in methanol 4 h; Heating;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
triethylamine in diethyl ether T=20°C; 9.5 h; Inert atmosphere;
参考文献
Murai, Kenichi; Miyazaki, Shuji; Fujioka, Hiromichi
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3746 - 3749
反应条件
methanol in hexanes; toluene T=20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; WATTERSON, Scott, Hunter; DYCKMAN, Alaric, J.; PITTS, William, J.; SPERGEL, Steven, H.
Patent: WO2010/85581 A1, 2010 ;
Location in patent: Page/Page column 82 ;
WO 2010/085581 A1
反应条件
in 1,3,5-trimethyl-benzene T=160 - 170°C; 20 h;
参考文献
Shimizu, Tomio; Hayashi, Yoshiyuki; Teramura, Kazuhiro
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 9 p. 2519 - 2522
反应条件
1: 59 percent / NaH / dimethylformamide / 1.5 h / 20 - 50 °C 2: 89 percent / NH2OH*HCl / methanol / 4 h / Heating View Scheme
参考文献
Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan; Adil; Nayak, V. Lakshma; Ramakrishna
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 273 - 280
反应条件
chloroformic acid ethyl ester; triethylamine in benzene 6 h; Heating;
参考文献
Shimizu, Tomio; Hayashi, Yoshiyuki; Shibafuchi, Hiroshi; Teramura, Kazuhiro
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 9 p. 2827 - 2832
反应条件
sulfuric acid 4 h; Reflux;
参考文献
Potkin, Vladimiri.; Petkevich, Sergeyk.; Lyakhov, Alexanders.; Ivashkevich, Ludmilas.
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-Z0796-OP, p. 260 - 264
反应条件
1: pyridine; sodium sulfate / methanol / 3 h / 20 °C / Inert atmosphere 2: silver tetrafluoroborate; phenol / tetrahydrofuran / 12 h / Reflux View Scheme
参考文献
Ueda, Masafumi; Ikeda, Yuki; Sato, Aoi; Ito, Yuta; Kakiuchi, Maiko; Shono, Hiroko; Miyoshi, Tetsuya; Naito, Takeaki; Miyata, Okiko
Tetrahedron, 2011 , vol. 67, # 25 p. 4612 - 4615
反应条件
methanol; hydroxylamine
参考文献
Jones et al.
Journal of the Chemical Society, 1950 , p. 236,240
