5-苯基异噁唑-3-甲酸甲酯合成路线 （共 19 条）
反应条件
sulfuric acid; hydroxylamine hydrochloride; sodium acetate 1.) MeOH, reflux, 1.5 h, pH 5, 2.) MeOH, reflux, 2 h, pH 3; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Dannhardt; Lambrecht; Laufer; Mutschler; Schweiger
Archiv der Pharmazie, 1995 , vol. 328, # 5 p. 437 - 443
反应条件
ammonia in water T=20°C; 12 h;
参考文献
Sechi, Mario; Sannia, Luciano; Orecchioni, Maria; Carta, Fabrizio; Paglietti, Giuseppe; Neamati, Nouri
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1097 - 1102
反应条件
in methanol T=110 - 112°C; 2 h; Green chemistry;
参考文献
Lavanya; Narayan Reddy; Saritha Jyostna; Ramsubba Reddy
Indian Journal of Heterocyclic Chemistry, 2011 , vol. 20, # 3 p. 279 - 280
反应条件
diisobutylaluminium hydride in dichloromethane; toluene T=-60°C; 1 h;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1: lithium hydroxide hydrate / tetrahydrofuran / 1 h / 50 °C 2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 24 h / 20 °C View Scheme
参考文献
Veeraswamy; Kurumurthy; Santhosh Kumar; Sambasiva Rao; Thelakkat, Kavya; Kotamraju, Srigiridhar; Narsaiah
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 9 p. 1369 - 1375
反应条件
lithium hydroxide hydrate in tetrahydrofuran T=50°C; 1 h;
参考文献
Veeraswamy; Kurumurthy; Santhosh Kumar; Sambasiva Rao; Thelakkat, Kavya; Kotamraju, Srigiridhar; Narsaiah
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 9 p. 1369 - 1375
反应条件
in methanol T=110 - 112°C; 2 h; Green chemistry;
参考文献
Lavanya; Narayan Reddy; Saritha Jyostna; Ramsubba Reddy
Indian Journal of Heterocyclic Chemistry, 2011 , vol. 20, # 3 p. 279 - 280
反应条件
1: in tetrahydrofuran
T=-78°C; Inert atmosphere;
2: With ammonium chloride in tetrahydrofuran; water
T=-78 - 20°C;
参考文献
Murai, Kenichi; Miyazaki, Shuji; Fujioka, Hiromichi
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3746 - 3749
反应条件
1: in tetrahydrofuran
T=-78°C; Inert atmosphere;
2: With ammonium chloride in tetrahydrofuran; water
T=-78 - 20°C;
参考文献
Murai, Kenichi; Miyazaki, Shuji; Fujioka, Hiromichi
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3746 - 3749
