α-乙酰基-γ-丁内酯合成路线 （共 116 条）
反应条件
sulfuryl dichloride T=-10 - 20°C; 25 h; Inert atmosphere;
参考文献
Herbert, John M.; Le Strat, Franck; Oumeddour, Delphine G.; Passey, Stephen C.; Taylor, Keith; Whitehead, David M.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 2 p. 89 - 92
反应条件
1: With ethanol; sodium 16 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
SOLVAY PHARMACEUTICALS B.V.
Patent: US2006/122206 A1, 2006 ;
Location in patent: Page/Page column 4 ;
US 20060122206 A1
反应条件
1: 83 percent / MeONa / benzene 2: 89 percent / aq. HCl / Heating View Scheme
参考文献
Cornish Christopher A.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2585 - 2598
反应条件
1: 89 percent / SO2Cl2
2: HCl / acetic acid / Heating
3: 43 percent / AcOH; AcONH4; 3 Angstroem molecular sieves / toluene / 6 h / Heating
4: 82 percent / Na2S; AcOH / ethanol / 2 h / -40 - -10 °C
5: 93 percent / CuBr2; t-BuONO / acetonitrile / 0.5 h / 0 °C
6: 94 percent / Zn; AcOH / 16 h / Heating
View Scheme
参考文献
Hawksley, Daniel; Griffin, David A.; Leeper, Finian J.
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 2 p. 144 - 148
反应条件
hydrogen iodide in water
参考文献
Cornish Christopher A.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2585 - 2598
反应条件
1: HBr
2: TsOH / benzene
3: 97 percent / NaI, NaHCO3 / acetone / 4 h / Ambient temperature
View Scheme
参考文献
Cornish Christopher A.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2585 - 2598
反应条件
1: 68 percent / HI / H2O
2: 70 percent / toluene-p-sulphonic acid / toluene / 24 h / Heating
3: 2.) 30percent sodium hydroxide / 1.) toluene, reflux, 2 d; 2.) water, reflux, 2 h
4: 70 percent / butyl-lithium / tetrahydrofuran / 1.) 0 degC, 15 min, 2.) -78 degC to R. T.
5: 84 percent / 50percent sodium hydride / dimethylformamide / 1 h / 50 °C
View Scheme
参考文献
Cornish, Christopher A.; Warren, Stuart
Tetrahedron Letters, 1983 , vol. 24, # 25 p. 2603 - 2606
反应条件
dihydrogen peroxide; copper(l) chloride in water; butanone; tert-butyl alcohol
T=20°C; 12 h; Acidic conditions;
参考文献
Dichtl, Alexander; Seyfried, Martin; Schoening, Kai-Uwe
Synlett, 2008 , # 12 p. 1877 - 1881
反应条件
1: 80 percent / HBr / H2O / Heating
2: 80 percent / p-TsOH / benzene / Heating
View Scheme
参考文献
Baldwin; Li
Journal of the Chemical Society - Series Chemical Communications, 1988 , # 4 p. 261 - 263
反应条件
1: 92 percent / dimethylformamide / 2 h / 120 °C
2: 1.) ozone / 1.) methylene chloride, -78 deg C, 2.) reflux
View Scheme
参考文献
Scarborough,R.M.; Smith,A.B.
Tetrahedron Letters, 1977 , p. 4361 - 4364
