α-乙酰基-γ-丁内酯合成路线 （共 116 条）
参考文献
Malawska, Barbara; Gorczyca, Maria
Acta Poloniae Pharmaceutica, 1994 , vol. 51, # 1 p. 63 - 68
反应条件
1: aq. NaBr, H2SO4
2: (i) KOEt, EtOH, (ii) /BRN= 1699406/
3: (i) HCl, benzene, (ii) PhNMe2
4: KOH / methanol
View Scheme
参考文献
Jaeger,H.; Keymer,R.
Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1960 , vol. 293, p. 896 - 900
反应条件
1: ethanol
2: SOCl2
View Scheme
参考文献
Schrage; Hitchings
Journal of Organic Chemistry, 1951 , vol. 16, p. 1153,1155
反应条件
1: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 15 min
2: 85 percent / H2O2 / CH2Cl2 / 4 h / 0 - 20 °C
3: 78 percent / 400 °C / 1 Torr
View Scheme
参考文献
Liotta, Dennis; Saindane, Manohar; Barnum, Christopher; Ensley, Harry; Balakrishnan, Pattabiraman
Tetrahedron Letters, 1981 , vol. 22, # 32 p. 3043 - 3046
反应条件
1: trichlorophosphate / toluene
2: hydrogen; palladium 10 on activated carbon; hydrogenchloride / methanol
View Scheme
参考文献
Xu, Weichu; Wright, George E.; Yanachkova, Milka; Yanachkov, Ivan B.
Letters in Organic Chemistry, 2014 , vol. 11, # 6 p. 470 - 473
反应条件
1: 68 percent / HI / H2O
2: 70 percent / toluene-p-sulphonic acid / toluene / 24 h / Heating
3: 2.) 30percent sodium hydroxide / 1.) toluene, reflux, 2 d; 2.) water, reflux, 2 h
View Scheme
参考文献
Cornish, Christopher A.; Warren, Stuart
Tetrahedron Letters, 1983 , vol. 24, # 25 p. 2603 - 2606
反应条件
1: 1) NaH / 1) DMF, 0 deg C, 2) DMF, 30 min
2: 76 percent / glacial acetic acid, HBr (30percent) / 3 h / Heating
View Scheme
参考文献
Krohn, Karsten; Baltus, Wolfgang
Liebigs Annalen der Chemie, 1982 , # 8 p. 1579 - 1581
反应条件
sodium ethanolate; sodium amide
1) toluene, reflux, 16 h; 2) EtOH, r.t., 24 h; Yield given. Multistep reaction;
参考文献
Lehmann; Reusch
Archiv der Pharmazie, 1983 , vol. 316, # 11 p. 955 - 960
反应条件
sodium ethanolate in ethanol
1) reflux, 16 h; 2) r.t., 24 h;
参考文献
Lehmann; Reusch
Archiv der Pharmazie, 1983 , vol. 316, # 11 p. 955 - 960
反应条件
sodium ethanolate in ethanol
1) reflux, 16 h; 2) r.t., 24 h;
参考文献
Lehmann; Reusch
Archiv der Pharmazie, 1983 , vol. 316, # 11 p. 955 - 960
