3,5-二甲氧基苯甲酰肼合成路线 （共 27 条）
反应条件
1: 63 percent / sodium nitrite, hydrochloric acid (2M), acetic acid (glacial) / H2O / 1 h / -10 °C
2: 93 percent / toluene / 2.5 h / Heating
3: 8.7 g / sodium hydroxide (20percent) / 60 °C
7: 28.8 g / fluoroboric acid, sodium nitrite / H2O
8: 7.6 g / warming, distillation
9: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 63 percent / sodium nitrite, hydrochloric acid (2M), acetic acid (glacial) / H2O / 1 h / -10 °C
2: 93 percent / toluene / 2.5 h / Heating
3: 8.7 g / sodium hydroxide (20percent) / 60 °C
7: 28.8 g / fluoroboric acid, sodium nitrite / H2O
8: 7.6 g / warming, distillation
9: 1.) lithium / 1.) ether, 2 h
10: decarboxylation
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
hydrogenchloride; acetic acid; sodium nitrite in water
T=-10°C; 1 h;
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 63 percent / sodium nitrite, hydrochloric acid (2M), acetic acid (glacial) / H2O / 1 h / -10 °C
2: 93 percent / toluene / 2.5 h / Heating
3: 8.7 g / sodium hydroxide (20percent) / 60 °C
7: 28.8 g / fluoroboric acid, sodium nitrite / H2O
8: 7.6 g / warming, distillation
9: 1.456 g / boron tribromide / CH2Cl2 / 52 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
in dichloromethane
T=20°C;
参考文献
Shi, Feng; Shen, Jing Kang; Chen, Danqi; Fog, Karina; Thirstrup, Kenneth; Hentzer, Morten; Karlsson, Jens-Jakob; Menon, Veena; Jones, Kenneth A.; Smith, Kelli E.; Smith, Garrick
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 4 p. 303 - 306
反应条件
1: 63 percent / sodium nitrite, hydrochloric acid (2M), acetic acid (glacial) / H2O / 1 h / -10 °C
2: 93 percent / toluene / 2.5 h / Heating
3: 8.7 g / sodium hydroxide (20percent) / 60 °C
7: 28.8 g / fluoroboric acid, sodium nitrite / H2O
8: 7.6 g / warming, distillation
9: 1.) lithium / 1.) ether, 2 h
10: Cu-quinoline
11: boron tribromide, pyridine hydrochloride / CH2Cl2 / 24 h / -78 °C
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 63 percent / sodium nitrite, hydrochloric acid (2M), acetic acid (glacial) / H2O / 1 h / -10 °C
2: 93 percent / toluene / 2.5 h / Heating
3: 8.7 g / sodium hydroxide (20percent) / 60 °C
7: 28.8 g / fluoroboric acid, sodium nitrite / H2O
8: 7.6 g / warming, distillation
9: 1.) lithium / 1.) ether, 2 h
10: Cu-quinoline
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
