乙基3-(4-甲氧基苯基)-2-丙炔酸酯合成路线 （共 27 条）
反应条件
sodium hydroxide Heating; Yield given;
参考文献
Jacobsen, Eric N.; Deng, Li; Furukawa, Yoshiro; Martinez, Luis E.
Tetrahedron, 1994 , vol. 50, # 15 p. 4323 - 4334
反应条件
diethyl ether; sodium ethanolate
参考文献
El-Kholy et al.
Journal of the Chemical Society, 1959 , p. 2588,2591
反应条件
in dichloromethane T=-30°C; 0.5 h;
参考文献
Vasilyev, Aleksander V.; Walspurger, Stephane; Chassaing, Stefan; Pale, Patrick; Sommer, Jean
European Journal of Organic Chemistry, 2007 , # 34 p. 5740 - 5748
反应条件
quinoline; hydrogen; Lindlar's catalyst in hexane P=760 Torr; Ambient temperature;
参考文献
Tetrahedron, , vol. 50, # 15 p. 4323 - 4334
反应条件
methyl(diphenyl)-phosphine in toluene
T=110°C; 5 h; Inert atmosphere;
参考文献
Siby, Acetou; Loreau, Olivier; Taran, Frederic
Synthesis, 2009 , # 14 art. no. Z05209SS, p. 2365 - 2370
反应条件
1: 2.3 percent Chromat. / quinoline, H2 / Lindlar catalyst / hexane; various solvent(s) / 760 Torr / Ambient temperature
2: 99 percent / Br2
3: 51 percent / KOH / aq. ethanol / 12 h / Heating
4: 81 percent / DCC, 4-dimethylaminopyridine / CH2Cl2 / 12 h / Ambient temperature
5: quinoline, H2 / Lindlar catalyst / hexane; various solvent(s) / 760 Torr / Ambient temperature
View Scheme
参考文献
Jacobsen, Eric N.; Deng, Li; Furukawa, Yoshiro; Martinez, Luis E.
Tetrahedron, 1994 , vol. 50, # 15 p. 4323 - 4334
反应条件
1: propynoic acid ethyl ester With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: With zinc(II) chloride in tetrahydrofuran
T=20°C; 1 h;
3: para-iodoanisole With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=50°C; 3 h;
参考文献
Li, Yi; Hesse, Manfred
Helvetica Chimica Acta, 2003 , vol. 86, # 2 p. 310 - 323
反应条件
1: 4-ethynyl-1-methoxy-benzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1.5 h; Inert atmosphere;
2: chloroformic acid ethyl ester in tetrahydrofuran; hexane
T=20°C; 19 h; Inert atmosphere;
参考文献
O'Rourke, Natasha F.; Wulff, Jeremy E.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1292 - 1308
反应条件
copper(l) iodide; air; caesium carbonate; silver(l) oxide in dichloromethane
T=80°C; Sonogashira type reaction; 36 h;
参考文献
Pan, Changduo; Luo, Fang; Wang, Wenhui; Ye, Zhishi; Cheng, Jiang
Tetrahedron Letters, 2009 , vol. 50, # 35 p. 5044 - 5046
反应条件
palladium 10 on activated carbon; oxygen; tetra-(n-butyl)ammonium iodide in 1,4-dioxane
T=80°C; P=760.051 Torr; 8 h; Autoclave;
参考文献
Gadge, Sandip T.; Bhanage, Bhalchandra M.
Synlett, 2013 , vol. 24, # 8 art. no. ST-2013-D0181-L, p. 981 - 986
