乙基3-(4-甲氧基苯基)-2-丙炔酸酯合成路线 （共 27 条）
反应条件
AgCl; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=50°C; 12 h;
参考文献
Lecercle, Delphine; Mothes, Celine; Taran, Frederic
Synthetic Communications, 2007 , vol. 37, # 8 p. 1301 - 1311
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; N,N-dimethyl-formamide
T=60 - 80°C; 22 h;
参考文献
Liang, Yan; Zhang, Ying Peng; Yu, Wei
Chinese Chemical Letters, 2012 , vol. 23, # 7 p. 777 - 780
反应条件
1: 4-methoxy-benzaldehyde With TMSC(Li)N2 in tetrahydrofuran; hexane
T=-78 - 20°C; 1.5 h;
2: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
3: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Further stages.;
参考文献
Hari, Yoshiyuki; Date, Koji; Aoyama, Toyohiko
Heterocycles, 2007 , vol. 74, # C p. 545 - 552
反应条件
T=500°C; P=0.1 - 1 Torr;
参考文献
Aitken, R. Alan; Horsburg, Caroline E. R.; McCreadie, J. Graeme; Seth, Shirley
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 13 p. 1727 - 1732
反应条件
1: 4-methoxy-benzaldehyde With TMSC(Li)N2 in tetrahydrofuran; hexane
T=-78 - 20°C; 1.5 h;
2: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
3: chloroformic acid ethyl ester in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Further stages.;
参考文献
Hari, Yoshiyuki; Date, Koji; Aoyama, Toyohiko
Heterocycles, 2007 , vol. 74, # C p. 545 - 552
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; hexane
T=50°C; 3 h;
参考文献
Sakamoto; Shiga; Yasuhara; Uchiyama; Kondo; Yamanaka
Synthesis, 1992 , # 8 p. 746 - 748
反应条件
1: Et3N / (PPh3)2PdCl2, CuI / 2 h / Ambient temperature
2: p-toluenesulfonic acid / benzene / 12 h / Ambient temperature
View Scheme
参考文献
Sakamoto; Shiga; Yasuhara; Uchiyama; Kondo; Yamanaka
Synthesis, 1992 , # 8 p. 746 - 748
反应条件
toluene-4-sulfonic acid
20 h; Heating;
参考文献
Jacobsen, Eric N.; Deng, Li; Furukawa, Yoshiro; Martinez, Luis E.
Tetrahedron, 1994 , vol. 50, # 15 p. 4323 - 4334
反应条件
potassium carbonate in methanol
T=60°C; 4 h;
参考文献
Chenault, Jaques; Dupin, Jean-Francois E.
Synthesis, 1987 , # 5 p. 498 - 499
反应条件
tributyl-amine; palladium diacetate
P=760 Torr; 1 h; Ambient temperature;
参考文献
Kitamura, Tsugio; Mihara, Ichiro; Taniguchi, Hiroshi; Stang, Peter J.
Journal of the Chemical Society, Chemical Communications, 1990 , # 8 p. 614 - 615
