乙基3-(4-甲氧基苯基)-2-丙炔酸酯合成路线 (共 27 条)
反应条件
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C / |Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / |Inert atmosphere
2.2: 19 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
O'Rourke, Natasha F.; Wulff, Jeremy E.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1292 - 1308
反应条件
1: bromine / CCl4 / Heating
2: 1.) KOtBu, 2.) esterification / 1.) ethanol, 70 deg C
View Scheme
参考文献
Butt, G.; Topsom, R. D.
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1982 , vol. 38, # 6 p. 649 - 654
反应条件
1: 70 percent / Et3N / toluene / 3 h / Ambient temperature
2: 92 percent / 500 °C / 0.1 - 1 Torr
View Scheme
参考文献
Aitken, R. Alan; Horsburg, Caroline E. R.; McCreadie, J. Graeme; Seth, Shirley
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 13 p. 1727 - 1732
反应条件
in tetrahydrofuran
3 h; Heating;
参考文献
Hari, Yoshiyuki; Date, Koji; Kondo, Ryosuke; Aoyama, Toyohiko
Tetrahedron Letters, 2008 , vol. 49, # 33 p. 4965 - 4967
反应条件
potassium tert-butylate
1.) ethanol, 70 deg C; Multistep reaction;
参考文献
Butt, G.; Topsom, R. D.
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1982 , vol. 38, # 6 p. 649 - 654
参考文献
Hariharan; Sudborough
Journal of the Indian Institute of Science, 1925 , vol. <A> 8, p. 216
Chem. Zentralbl., 1926 , vol. 97, # I p. 72
参考文献
Hariharan; Sudborough
Journal of the Indian Institute of Science, 1925 , vol. <A> 8, p. 216
Chem. Zentralbl., 1926 , vol. 97, # I p. 72