1-氯-4-(苯基乙炔基)苯合成路线 （共 58 条）
反应条件
caesium carbonate; bis(dibenzylideneacetone)-palladium(0) in methanol
T=20°C; Suzuki-Miyaura cross-coupling reaction; 12 h; Under air;
参考文献
Tang, Jian-Sheng; Tian, Mi; Sheng, Wen-Bing; Guo, Can-Cheng
Synthesis, 2012 , vol. 44, # 4 p. 541 - 546
反应条件
copper(l) iodide; 8-hydroxy-quinoline; potassium carbonate in N,N-dimethyl-formamide
T=110°C; 24 h; Inert atmosphere;
参考文献
Yan, Hong; Lu, Linhua; Sun, Peng; Zhu, Yan; Yang, Hailong; Liu, Defu; Rong, Guangwei; Mao, Jincheng
RSC Advances, 2013 , vol. 3, # 2 p. 377 - 381
反应条件
copper(l) iodide; air; caesium carbonate; silver(l) oxide in dichloromethane
T=80°C; Sonogashira type reaction; 36 h;
参考文献
Pan, Changduo; Luo, Fang; Wang, Wenhui; Ye, Zhishi; Cheng, Jiang
Tetrahedron Letters, 2009 , vol. 50, # 35 p. 5044 - 5046
反应条件
1: methyl (2-phenylethynyl) sulfide With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether in tetrahydrofuran
0.166667 h; Inert atmosphere;
2: C6H4ClIZn*ClLi in tetrahydrofuran
T=25°C; 24 h; Inert atmosphere;
参考文献
Melzig, Laurin; Metzger, Albrecht; Knochel, Paul
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2948 - 2956
反应条件
SPhos; C16H16Cl2N2O4Pd2; N-hexadecyl-N,N,N-trimethylammonium bromide; triethylamine in water
T=130°C; Sonogashira Cross-Coupling; 0.5 h; Microwave irradiation;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 203 - 208
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=85°C; 0.333333 h;
参考文献
Katritzky, Alan R.; Gordeev, Mikhail F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 11 p. 1295 - 1298
反应条件
1,3-dimethyl-imidazolidin-2-one; potassium carbonate; triphenylphosphine; copper(l) chloride
T=120°C; 12 h;
参考文献
Ogawa, Daisuke; Li, Jing; Suetsugu, Masato; Jiao, Jiao; Iwasaki, Masayuki; Nishihara, Yasushi
Tetrahedron Letters, 2013 , vol. 54, # 6 p. 518 - 521
反应条件
potassium carbonate; chlorobenzene in ethanol
Sonogashira Cross-Coupling; 18 h; Green chemistry;
参考文献
Wang, Hu; Li, Li; Bai, Xing-Feng; Deng, Wen-Hui; Zheng, Zhan-Jiang; Yang, Ke-Fang; Xu, Li-Wen
Green Chemistry, 2013 , vol. 15, # 9 p. 2349 - 2355
反应条件
1: iodobenzene; 2-methyl-but-3-yn-2-ol With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine
T=50°C; 1 h; Inert atmosphere;
2: 1-chloro-4-iodobenzene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hydroxide
T=110°C; 5 h; Inert atmosphere;
参考文献
Zhao, Yankai; Liu, Qiang; Li, Jing; Liu, Zhongquan; Zhou, Bo
Synlett, 2010 , # 12 p. 1870 - 1872
反应条件
phosphorus pentachloride
Erhitzen des Reaktionsprodukts mit Natrium-tert-butylat in tert-Butylalkohol;
参考文献
Newman; Reid
Journal of Organic Chemistry, 1958 , vol. 23, p. 665
