1-氯-4-(苯基乙炔基)苯合成路线 （共 58 条）
反应条件
1: SPHOS; tris-(dibenzylideneacetone)dipalladium(0); tetra-n-butylammonium fluoride trihydrate / 1-methyl-pyrrolidin-2-one; water / 4 h / 50 °C
2: 1-methyl-pyrrolidin-2-one / 14 h / 80 °C
View Scheme
参考文献
Tartaggia, Stefano; De Lucchi, Ottorino; Goossen, Lukas J.
European Journal of Organic Chemistry, 2012 , # 7 p. 1431 - 1438
反应条件
1: SPHOS; bis(η3-allyl-μ-chloropalladium(II)); tetra-n-butylammonium fluoride trihydrate / 1-methyl-pyrrolidin-2-one; water / 16 h / 50 °C / Inert atmosphere
2: 1-methyl-pyrrolidin-2-one / 14 h / 80 °C
View Scheme
参考文献
Tartaggia, Stefano; De Lucchi, Ottorino; Goossen, Lukas J.
European Journal of Organic Chemistry, 2012 , # 7 p. 1431 - 1438
反应条件
1.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
1.2: -78 - 0 °C / Inert atmosphere
2.1: lanthanum; iodine / tetrahydrofuran / 3 h / 67 °C / Inert atmosphere
View Scheme
参考文献
Umeda, Rui; Yuasa, Takumi; Anahara, Namika; Nishiyama, Yutaka
Journal of Organometallic Chemistry, 2011 , vol. 696, # 9 p. 1916 - 1919
反应条件
in 1-methyl-pyrrolidin-2-one
T=80°C; 14 h;
参考文献
Tartaggia, Stefano; De Lucchi, Ottorino; Goossen, Lukas J.
European Journal of Organic Chemistry, 2012 , # 7 p. 1431 - 1438
反应条件
in neat (no solvent)
T=110°C; 6 h; Yield given. Yields of byproduct given;
参考文献
Akiba, Kin-ya; Okinaka, Takaaki; Nakatani, Masayuki; Yamamoto, Yohsuke
Tetrahedron Letters, 1987 , vol. 28, # 29 p. 3367 - 3368
反应条件
triphenylphosphine in tetrahydrofuran
T=70°C; Negishi Coupling; 24 h; Inert atmosphereGreen chemistry; Catalytic behavior;
参考文献
Wu, Wei-Yi; Lin, Tze-Chiao; Takahashi, Tamotsu; Tsai, Fu-Yu; Mou, Chung-Yuan
ChemCatChem, 2013 , vol. 5, # 4 p. 1011 - 1019
反应条件
potassium hydroxide in 1,4-dioxane
参考文献
Dombrovskii,A.V.; Taschchuk,K.G.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 1 p. 165 - 170,158 - 162
反应条件
tetra-n-butylammonium acetate; potassium carbonate; [(dipyridin-2-ylmethyl)NHCONHCy]Pd(II)Cl2 in water
T=100°C; modified Sonogashira-Cassar-Heck coupling; 7 h; Product distribution; Further Variations:CatalystsReagentsReaction partnersTemperatures;
参考文献
Gil-Molto, Juan; Najera, Carmen
European Journal of Organic Chemistry, 2005 , # 19 p. 4073 - 4081
反应条件
1: 56 percent / t-BuOK / 1.) THF, -10 deg C, 10 min, 2.) THF, 25 deg C, 18 h
2: 70 percent / t-BuOK / dimethylformamide / 0.17 h / 85 °C
View Scheme
参考文献
Katritzky, Alan R.; Gordeev, Mikhail F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 11 p. 1295 - 1298
反应条件
1: 56 percent / t-BuOK / 1.) THF, -10 deg C, 10 min, 2.) THF, 25 deg C, 18 h
2: 70 percent / t-BuOK / dimethylformamide / 0.17 h / 85 °C
View Scheme
参考文献
Katritzky, Alan R.; Gordeev, Mikhail F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 11 p. 1295 - 1298
