1-氯-4-(苯基乙炔基)苯合成路线 （共 58 条）
反应条件
1: CuCl2*2H2O / aq. HCl
2: KOH / dioxane
View Scheme
参考文献
Dombrovskii,A.V.; Taschchuk,K.G.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 1 p. 165 - 170,158 - 162
反应条件
1: CuCl2*2H2O / aq. HCl
2: KOH / dioxane
View Scheme
参考文献
Dombrovskii,A.V.; Taschchuk,K.G.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 1 p. 165 - 170,158 - 162
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / tetrahydrofuran / 0.17 h / Inert atmosphere
2.2: 24 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Melzig, Laurin; Metzger, Albrecht; Knochel, Paul
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2948 - 2956
反应条件
1: triphenylphosphine / dichloromethane / 0 °C
2: copper(l) iodide; 8-hydroxy-quinoline; potassium phosphate / ethanol / 12 h / 100 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Liu, Jidan; Dai, Fenglin; Yang, Zhiyong; Wang, Sizhuo; Xie, Kai; Wang, Anwei; Chen, Xiang; Tan, Ze
Tetrahedron Letters, 2012 , vol. 53, # 42 p. 5678 - 5683
参考文献
Huggins, John M.; Bergman, Robert G.
Journal of the American Chemical Society, 1981 , vol. 103, # 11 p. 3002 - 3011
参考文献
Theis,R.J.; Dessy,R.E.
Journal of Organic Chemistry, 1966 , vol. 31, p. 624 - 625
反应条件
1: N2H4*H2O / Ambient temperature
2: CF3CO2Hg
View Scheme
参考文献
Theis,R.J.; Dessy,R.E.
Journal of Organic Chemistry, 1966 , vol. 31, p. 624 - 625
反应条件
(i) nBuLi, (ii) /BRN= 512043/; Multistep reaction;
参考文献
Colvin,E.W.; Hamill,B.D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 869 - 874
