反式-4-甲氧基-3-丁烯-2-酮合成路线 （共 40 条）
反应条件
1: (S)-(-)-2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde With (1R,2S) Jacobsen's chromium catalyst; BaO in ethyl acetate T=0 - 20°C; Inert atmosphere; 2: trans-1-methoxy-3-(trimethylsilyloxy)-1,3-butadiene in ethyl acetate T=0 - 4°C; hetero Diels-Alder reaction; DarknessInert atmosphere; 3: With trifluoroacetic acid in ethyl acetate T=0 - 20°C; Inert atmosphere; optical yield given as percent de;
参考文献
Smith III, Amos B.; Dong, Shuzhi
Organic Letters, 2009 , vol. 11, # 5 p. 1099 - 1102
反应条件
1: With BaO; (S,S)-(+)-Jacobsen salene complex in ethyl acetate T=0°C; hetero Diels-Alder reaction; 24 h; 2: With trifluoroacetic acid in dichloromethane; ethyl acetate T=0 - 20°C; 0.166667 h; Title compound not separated from byproducts;
参考文献
Paterson, Ian; Steven, Alan; Luckhurst, Chris A.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 20 p. 3026 - 3038
反应条件
in dichloromethane T=20°C;
参考文献
Mayr; Bug; Gotta; Hering; Irrgang; Janker; Kempf; Loos; Ofial; Remennikov; Schimmel
Journal of the American Chemical Society, 2001 , vol. 123, # 39 p. 9500 - 9512
反应条件
in chloroform-d1 T=55°C; 50 h; Title compound not separated from byproducts;
参考文献
Dowd, Paul; Weber, William
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4777 - 4779
反应条件
3 A molecular sieve; zinc(II) iodide in tetrahydrofuran T=20°C; 3 h; Yield given. Yields of byproduct given;
参考文献
Abraham, Herve; Theus, Elisabeth; Stella, Lucien
Bulletin des Societes Chimiques Belges, 1994 , vol. 103, # 7-8 p. 361 - 366
反应条件
benzoic acid T=20°C;
参考文献
Acocella, Maria Rosaria; Massa, Antonio; Palombi, Laura; Villano, Rosaria; Scettri, Arrigo
Tetrahedron Letters, 2005 , vol. 46, # 36 p. 6141 - 6144
反应条件
sodium acetate Heating;
参考文献
Duhamel; Guillemont; Poirier; Chabardes
Tetrahedron Letters, 1993 , vol. 34, # 26 p. 4197 - 4200
反应条件
other β-ketoaldehydes, other alcohols, var. solvents; Product distribution;
参考文献
Terpinski, Jacek; Zajaczkowska-Terpinska, Ewa
Polish Journal of Chemistry, 1981 , vol. 55, # 1 p. 79 - 88
反应条件
sodium bromide 1.) DMF, room temperature, 20 min, 2.) room temperature, 8-10 h; Yield given. Multistep reaction;
参考文献
Iqbal, Javed; Khan, M. Amin
Synthetic Communications, 1989 , vol. 19, # 3and4 p. 515 - 522
反应条件
in 2-methoxy-ethanol; water; acetic acid
参考文献
Rohm and Haas Company
Patent: US3965107 A1, 1976 ;
