反式-4-甲氧基-3-丁烯-2-酮合成路线 （共 40 条）
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
180 h; Ambient temperature;
参考文献
Duthaler, Rudolf O.
Helvetica Chimica Acta, 1983 , vol. 66, # 8 p. 2543 - 2563
反应条件
4 A molecular sieve; N-ethyl-N,N-diisopropylamine
1.) THF, r.t., 7.5 d; 2.) pyridine; Yield given. Multistep reaction;
参考文献
Duthaler, Rudolf O.
Helvetica Chimica Acta, 1983 , vol. 66, # 8 p. 2543 - 2563
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
180 h; Ambient temperature;
参考文献
Duthaler, Rudolf O.
Helvetica Chimica Acta, 1983 , vol. 66, # 8 p. 2543 - 2563
反应条件
4 A molecular sieve; N-ethyl-N,N-diisopropylamine
1.) THF, r.t., 7.5 d; 2.) pyridine; Yield given. Multistep reaction;
参考文献
Duthaler, Rudolf O.
Helvetica Chimica Acta, 1983 , vol. 66, # 8 p. 2543 - 2563
反应条件
1: 1.) LDA; / 1.) THF-HMPA-hexane, -78 deg C, 30 min, than -78 to -50 deg C, 1 h; 2.) THF-MHPA-hexane, -78 deg C, than -40 deg C, 1 h
2: 78 percent / p-TsOH / CH2Cl2 / 3 h / Ambient temperature
View Scheme
参考文献
kato, Michiharu; Saito, Hiroaki; Yoshikoshi, Akira
Chemistry Letters, 1984 , p. 213 - 216
反应条件
pyridine; chlorine
T=20°C; 0.0833333 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/5283 A1, 2004 ;
Location in patent: Page 69; 88 ;
WO 2004/005283 A1
反应条件
potassium hydroxide in water
T=25°C; 0.0833333 h;
参考文献
Nicolaou; Zhang, Hongjun; Chen, Jason S.; Crawford, James J.; Pasunoori, Laxman
Angewandte Chemie - International Edition, 2007 , vol. 46, # 25 p. 4704 - 4707
反应条件
acetic acid in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate; toluene
参考文献
Cassella Farbwerke Mainkur Aktiengesellschaft
Patent: US3969363 A1, 1976 ;
反应条件
1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 30 min, 2.) gradually warmed to room temp., 2-3 h, room temp.
2: 85 percent / trifluoroacetic acid / benzene / Ambient temperature; 12-18 h
View Scheme
参考文献
Koreeda, Masato; Akagi, Hiroshi
Tetrahedron Letters, 1980 , vol. 21, p. 1197 - 1200
反应条件
sodium hydroxide; palladium on charcoal in tetrahydrofuran; water
参考文献
Pfizer Inc.
Patent: US6251904 B1, 2001 ;
