4-氯-吡啶[3,4-D]嘧啶合成路线 （共 5 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide T=90°C; 1 h;
参考文献
Kudos Pharmaceuticals Ltd
Patent: US2006/199804 A1, 2006 ;
Location in patent: Page/Page column 30 ;
US 20060199804 A1
反应条件
1.1: thionyl chloride; N,N-dimethyl-formamide / 2 h / |Reflux 1.2: 2 h / 20 °C 2.1: |Reflux 3.1: trichlorophosphate; N,N-dimethyl-formamide / acetonitrile / 20 °C / |Reflux View Scheme
参考文献
INFINITY PHARMACEUTICALS INC.; INTELLIKINE, LLC; CASTRO, Alfredo, C.; EVANS, Catherine, A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel, A.; TREMBLAY, Martin, R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina
Patent: WO2013/12915 A1, 2013 ;
WO 2013/012915 A1
反应条件
1: |Reflux 2: trichlorophosphate; N,N-dimethyl-formamide / acetonitrile / 20 °C / |Reflux View Scheme
参考文献
INFINITY PHARMACEUTICALS INC.; INTELLIKINE, LLC; CASTRO, Alfredo, C.; EVANS, Catherine, A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel, A.; TREMBLAY, Martin, R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina
Patent: WO2013/12915 A1, 2013 ;
WO 2013/012915 A1
反应条件
1: NEt3 / benzene / 0.25 h / Heating
2: conc. HCl / acetic acid / 1 h / Heating
View Scheme
参考文献
Petric, Andrej; Tisler, M.; Stanovnik, Branko
Monatshefte fuer Chemie, 1983 , vol. 114, p. 615 - 624
反应条件
hydrazine in tetrahydrofuran
T=20°C; 5 h;
参考文献
Kudos Pharmaceuticals Ltd
Patent: US2006/199804 A1, 2006 ;
Location in patent: Page/Page column 30 ;
US 20060199804 A1
