1-氮杂双环[2.2.2]辛烷-3-羧醛合成路线 （共 5 条）
反应条件
diisobutylaluminium hydride in toluene
T=-65 - 20°C; 2.5 h;
参考文献
Bromidge, Steven M.; Brown, Frank; Cassidy, Frederick; Clark, Michael S. G.; Dabbs, Steven; Hadley, Michael S.; Hawkins, Julie; Loudon, Julia M.; Naylor, Christopher B.; Orlek, Barry S.; Riley, Graham J.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 26 p. 4265 - 4280
反应条件
perchloric acid in chloroform
0.25 h; Ambient temperature;
参考文献
Ricciardi, Fiore J.; Doukas, Peter H.
Heterocycles, 1986 , vol. 24, # 4 p. 971 - 977
反应条件
1: 61 percent / diethyl ether / -35 - 20 °C
2: perchloric acid / CHCl3 / 0.25 h / Ambient temperature
View Scheme
参考文献
Ricciardi, Fiore J.; Doukas, Peter H.
Heterocycles, 1986 , vol. 24, # 4 p. 971 - 977
反应条件
sulfuric acid; water
Hydrolysis; Dehydration; 1 h; Heating;
参考文献
Guminski, Yves; Fabre, Valerie; Lesimple, Patrick; Imbert, Thierry
Organic Preparations and Procedures International, 1999 , vol. 31, # 3 p. 319 - 323
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol
T=10°C; Reduction; 0.25 h;
参考文献
Guminski, Yves; Fabre, Valerie; Lesimple, Patrick; Imbert, Thierry
Organic Preparations and Procedures International, 1999 , vol. 31, # 3 p. 319 - 323
