1,3-二溴甲基-5-硝基苯合成路线 （共 8 条）
参考文献
Reich; Rose; Wilson
Journal of the Chemical Society, 1947 , p. 1234,1236
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
4 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/99317 A1, 2007 ;
Location in patent: Page/Page column 112 ;
WO 2007/099317 A1
反应条件
phosphorus tribromide in diethyl ether
T=0 - 20°C; 18 h;
参考文献
Chhikara, Bhupender S.; Kumar, Nitin; Tandon, Vibha; Mishra, Anil K.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4713 - 4720
参考文献
Tsuge, Akihiko; Matsushita, Ryuichiro; Sakura, Katsuhiko; Moriguchi, Tetsuji; Araki, Koji
Chemistry Letters, 2012 , vol. 41, # 5 p. 485 - 487
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
参考文献
State of Oregon Acting by and Through the State Board of Higher Education on Behalf of the University of Oregon
Patent: US5567411 A1, 1996 ;
反应条件
1: 92 percent / PCl5 / 2 h / 120 °C
2: 70 percent / NaBH4 / bis-(2-methoxy-ethyl) ether / 7 h / 20 °C
3: 97 percent / PBr3 / diethyl ether / 18 h / 0 - 20 °C
View Scheme
参考文献
Chhikara, Bhupender S.; Kumar, Nitin; Tandon, Vibha; Mishra, Anil K.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4713 - 4720
反应条件
1: 70 percent / NaBH4 / bis-(2-methoxy-ethyl) ether / 7 h / 20 °C
2: 97 percent / PBr3 / diethyl ether / 18 h / 0 - 20 °C
View Scheme
参考文献
Chhikara, Bhupender S.; Kumar, Nitin; Tandon, Vibha; Mishra, Anil K.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4713 - 4720
反应条件
1: NaBH4 / methanol
2: 94 percent / benzene / 2.5 h / Heating
View Scheme
参考文献
Staab, Heinz A.; Schanne, Lothar; Krieger, Claus; Taglieber, Volker
Chemische Berichte, 1985 , vol. 118, # 3 p. 1204 - 1229
