5-溴-1,3-二羟基甲苯合成路线 （共 9 条）
反应条件
pyridinium chlorochromate T=20°C; Oxidation;
参考文献
Catala, Laure; Turek, Philippe; Le Moigne, Jacques; De Cian, Andre; Kyritsakas, Nathalie
Tetrahedron Letters, 2000 , vol. 41, # 7 p. 1015 - 1018
反应条件
diisobutylaluminium hydride in dichloromethane; toluene
参考文献
Hoffmann-La Roche Inc.
Patent: US6617346 B1, 2003 ;
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol
T=0°C; 5 h; Cooling with ice;
参考文献
TEIJIN LIMITED
Patent: EP1460059 A1, 2004 ;
Location in patent: Page 8 ;
反应条件
borane-THF
Reduction;
参考文献
Catala, Laure; Turek, Philippe; Le Moigne, Jacques; De Cian, Andre; Kyritsakas, Nathalie
Tetrahedron Letters, 2000 , vol. 41, # 7 p. 1015 - 1018
反应条件
1: NBS, BPO / CCl4 / 24 h / Heating
2: acetic acid / 24 h / Heating
3: LiAlH4 / tetrahydrofuran / 2 h / 0 °C
View Scheme
参考文献
Osuka, Atsuhiro; Liu, Ben-li; Maruyama, Kazuhiro
Journal of Organic Chemistry, 1993 , vol. 58, # 13 p. 3582 - 3585
反应条件
1: acetic acid / 24 h / Heating
2: LiAlH4 / tetrahydrofuran / 2 h / 0 °C
View Scheme
参考文献
Osuka, Atsuhiro; Liu, Ben-li; Maruyama, Kazuhiro
Journal of Organic Chemistry, 1993 , vol. 58, # 13 p. 3582 - 3585
反应条件
1: 1.) HBr, NaNO2, 2.) CuBr, HBr / 1.) H2O, 2.) H2O, 0 deg C; heating, 1 h
2: 98 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating
View Scheme
参考文献
Brunner; Janura; Stefaniak
Synthesis, 1998 , # 12 p. 1742 - 1749
反应条件
1: 86 percent / Br2; silver sulfate; sulfuric acid
2: 93 percent / BH3*THF
View Scheme
参考文献
Catala, Laure; Turek, Philippe; Le Moigne, Jacques; De Cian, Andre; Kyritsakas, Nathalie
Tetrahedron Letters, 2000 , vol. 41, # 7 p. 1015 - 1018
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=20°C; 2 h;
参考文献
Huang, He; Li, Huiying; Martasek, Pavel; Roman, Linda J.; Poulos, Thomas L.; Silverman, Richard B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3024 - 3032
