2-氨基-6-氯-3,5-二氰基吡啶合成路线 （共 7 条）
反应条件
copper dichloride; isopentyl nitrite in acetonitrile T=65°C; 5 h;
参考文献
Vazquez Vilarelle, David; Peinador Veira, Carlos; Quintela Lopez, Jose M.
Tetrahedron, 2004 , vol. 60, # 2 p. 275 - 283
反应条件
hydrazine hydrate in ethanol 1 h; Reflux;
参考文献
Soliman
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 3 p. 592 - 596
反应条件
in N,N-dimethyl-formamide T=153°C; 0.25 h;
参考文献
Chioua, Mourad; Samadi, Abdelouahid; Soriano, Elena; Lozach, Olivier; Meijer, Laurent; Marco-Contelles, Jose
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 16 p. 4566 - 4569
反应条件
methanol
1.5 h; Reflux;
参考文献
Samadi, Abdelouahid; Marco-Contelles, Jose; Soriano, Elena; Alvarez-Perez, Monica; Chioua, Mourad; Romero, Alejandro; Gonzalez-Lafuente, Laura; Gandia, Luis; Roda, Jose M.; Lopez, Manuela G.; Villarroya, Mercedes; Garcia, Antonio G.; Rios, Cristobal De Los
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 16 p. 5861 - 5872
反应条件
hydrogen; palladium-barium carbonate in methanol; N,N-dimethyl-formamide
P=2585.7 Torr; 6 h;
参考文献
Southern Research Institute; Sloan-Kettering Institute for Cancer Research
Patent: US4725687 A1, 1988 ;
反应条件
ammonium hydroxide; acetone
参考文献
Little et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 2832,2834
Full Text Show Details
Du Pont de Nemours and Co.
Patent: US2794803 , 1955 ;
反应条件
formamide
T=180°C; Microwave irradiation;
参考文献
Samadi, Abdelouahid; Silva, Daniel; Chioua, Mourad; Carreiras, Maria Do Carmo; Marco-Contelles, Jose
Synthetic Communications, 2011 , vol. 41, # 19 p. 2859 - 2869
