4-氯-2-肼基-1,3-苯并噻唑合成路线 （共 6 条）
反应条件
T=100 - 105°C; P=60 - 65 Torr; 1 h;
参考文献
Zhang, Jing-Lin; Ma, Xiao-Bo
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 53, # 1-4 p. 291 - 298
反应条件
T=110 - 115°C; P=5 - 10 Torr; 1 h;
参考文献
Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 53, # 1-4 p. 291 - 298
反应条件
T=100 - 105°C; P=60 - 65 Torr; 1 h;
参考文献
Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 53, # 1-4 p. 291 - 298
反应条件
hydrogenchloride; hydrazine hydrate
T=150°C; 3 h; Inert atmosphere;
参考文献
COMPOUND HANDLING B.V.; STICHTING KATHOLIEKE UNIVERSITEIT; HOOIJ, VAN, Onno; SCHALKEN, Jacobus Antonius; VIËTOR, Hendrik Engelbertus; PIET, Dennis Patrick; MAAS, Petrus Emmanuel Marie; TIJHUIS, Johann Heinrich; DEERENBERG, Sirik; SPRENKELS, Nanda Elisabeth; TANG, Siu Ha
Patent: WO2013/131931 A1, 2013 ;
Location in patent: Page/Page column 28; 29 ;
反应条件
1: ammonia; bromine; acetic acid
2: hydrogenchloride; hydrazine hydrate / water; ethylene glycol / Reflux
View Scheme
参考文献
Patel, Navin B.; Khan, Imran H.; Rajani, Smita D.
Archiv der Pharmazie, 2010 , vol. 343, # 11-12 p. 692 - 699
反应条件
hydrazine hydrate in ethanol; water
3 h; Reflux;
参考文献
Stella, Alessandro; Segers, Kenneth; De Jonghe, Steven; Vanderhoydonck, Bart; Rozenski, Jef; Anne, Jozef; Herdewijn, Piet
Chemistry and Biodiversity, 2011 , vol. 8, # 2 p. 253 - 265
