7-氯-3,4-二氢-1H-苯并[E][1,4]二氮杂卓-2,5-二酮合成路线 （共 6 条）
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic acid
参考文献
State of Oregon, Acting by and through the Oregon State Board of Higher Education, Acting for and on Behalf of the Oregon Health Sciences University and the University of Oregon; Acea Pharmaceuticals, Inc.; The Regents of the University of California
Patent: US5597922 A1, 1997 ;
US 5597922 A
反应条件
1: pyridine / 24 h / Heating 2: acetic acid / 24 h View Scheme
参考文献
Gates, Marshall
Journal of Organic Chemistry, 1980 , vol. 45, # 9 p. 1675 - 1681
反应条件
in various solvent(s) T=250 - 260°C; 10 h;
参考文献
Gupta, Renu; Sirohi, Reenu; Shastri, Sudha; Kishore
Heterocyclic Communications, 2003 , vol. 9, # 4 p. 363 - 366
参考文献
Sabb, Annmarie L.; Vogel, Robert L.; Welmaker, Gregory S.; Sabalski, Joan E.; Coupet, Joseph; Dunlop, John; Rosenzweig-Lipson, Sharon; Harrison, Boyd
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2603 - 2607
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 24 h;
参考文献
Wyeth
Patent: US2004/9970 A1, 2004 ;
Location in patent: Page/Page column 15 ;
US 20040009970 A1
反应条件
1: lithium aluminum hydride / tetrahydrofuran / 24 h
2: TEA / 24 h / 20 °C
View Scheme
参考文献
Sabb, Annmarie L.; Vogel, Robert L.; Welmaker, Gregory S.; Sabalski, Joan E.; Coupet, Joseph; Dunlop, John; Rosenzweig-Lipson, Sharon; Harrison, Boyd
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2603 - 2607
