2-(2,4-二氟苯基)丙-2-醇合成路线 (共 2 条)
反应条件
1: in diethyl ether T=0 - 20°C; 2: With water in diethyl ether
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/135842 A1, 2009 ;
Location in patent: Page/Page column 71-72 ;
WO 2009/135842 A1
反应条件
n-butyllithium in diethyl ether 1.) -78 deg C, 2.) -78 deg C to room temperature;
参考文献
Coe, Paul Leslie; Waring, Anthony John; Yarwood, Thomas David
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 21 p. 2729 - 2738