5-溴-3-氟苯-1,2-二胺合成路线

517920-70-62-氟-4-溴-6-硝基苯胺

517920-69-35-溴-3-氟苯-1,2-二胺

参考文献

WO2012/83170 A1, ;

Page/Page column 156-157 ;

1193385-18-05-溴-3-氟-2-硝基-苯胺

517920-69-35-溴-3-氟苯-1,2-二胺

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 24 p. 6390 - 6393

4845-50-52,3-二羟基-1,4-二氧杂环己烷+

517920-69-35-溴-3-氟苯-1,2-二胺

1210048-05-77-溴-5-氟喹噁啉

参考文献

BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan
Patent: WO2010/20363 A1, 2010 ;
Location in patent: Page/Page column 117 ;

131543-46-9+

517920-69-35-溴-3-氟苯-1,2-二胺

1210048-05-77-溴-5-氟喹噁啉

参考文献

UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne
Patent: WO2010/52448 A2, 2010 ;
Location in patent: Page/Page column 70 ;
WO 2010/052448 A2

64-18-6甲酸+

517920-69-35-溴-3-氟苯-1,2-二胺

1197944-23-2

参考文献

MERCK SERONO S.A.; MUZERELLE, Mathilde; QUATTROPANI, Anna; MONTAGNE, Cyril; DORBAIS, Jerome
Patent: WO2010/69949 A1, 2010 ;
Location in patent: Page/Page column 50 ;