反应条件
1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane / 12 h / 0 - 20 °C / |Inert atmosphere 2.1: n-butyllithium / diethyl ether; tetrahydrofuran; hexane / 0.42 h / -78 °C / |Inert atmosphere 2.2: 1.08 h / -78 - 0 °C / |Inert atmosphere 3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 °C / |Inert atmosphere 3.2: 0.5 h / -78 - 0 °C / |Inert atmosphere 4.1: lithium triethylborohydride / tetrahydrofuran; toluene / 0.5 h / -78 °C / |Inert atmosphere 4.2: 12 h / 20 °C / |Inert atmosphere 5.1: potassium carbonate; palladium diacetate; dibenzyl hydrogen phosphate / 1,1-dimethylpropan-1-ol / 50 h / 110 °C / |Inert atmosphere 6.1: trifluoroacetic acid / tetrahydrofuran; water / 27 h / 0 - 25 °C / |Inert atmosphere View Scheme
参考文献
Ting, Chi P.; Maimone, Thomas J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3115 - 3119
Angew. Chem., 2014 , vol. 126, # 12 p. 3179 - 3183,5