2-丙基-4,5-二氰基咪唑合成路线 （共 10 条）
反应条件
1: in acetonitrile 5 h; RefluxLarge scale reaction; 2: in toluene Reflux;
参考文献
Babu, Karrothu Srihari; Reddy, Mallepalli Srinivasa; Tagore, Amirisetty Ravindranath; Reddy, Gade Srinivas; Sebastian, Sony; Varma, Mudunuru Satish; Venkateswarlu, Gandu; Bhattacharya, Apurba; Reddy, Padi Pratap; Anand, Ramasamy Vijaya
Synthetic Communications, 2009 , vol. 39, # 2 p. 291 - 298
反应条件
trifluoroacetic acid in 1,4-dioxane 8 h; Heating;
参考文献
Bukowska; Prejzner; Szczecinski
Polish Journal of Chemistry, 2004 , vol. 78, # 3 p. 417 - 422
参考文献
Sankyo Company, Limited
Patent: US5616599 A1, 1997 ;
US 5616599 A
反应条件
1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature 3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 4: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 5: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature 6: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 323 - 338
反应条件
hydrogenchloride; water 4 h; RefluxLarge scale reaction;
参考文献
Babu, Karrothu Srihari; Reddy, Mallepalli Srinivasa; Tagore, Amirisetty Ravindranath; Reddy, Gade Srinivas; Sebastian, Sony; Varma, Mudunuru Satish; Venkateswarlu, Gandu; Bhattacharya, Apurba; Reddy, Padi Pratap; Anand, Ramasamy Vijaya
Synthetic Communications, 2009 , vol. 39, # 2 p. 291 - 298
反应条件
1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature 3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 4: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 5: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature 6: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C 7: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C View Scheme
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
反应条件
1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature 3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C View Scheme
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
反应条件
1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
反应条件
1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature 3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 4: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h View Scheme
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
反应条件
1: 81 percent / tetrahydrofuran / 0.5 h / 10 - 15 °C 2: 6N aq. HCl / 8 h / Heating 3: HCl / 16 h / Ambient temperature 4: 69 percent / tetrahydrofuran / 2.5 h / -40 °C View Scheme
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
