hydroxylamine in water; isopropyl alcohol T=58 - 60°C; 5.42 h; Large scale reaction;

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / -15 °C 1.2: 11 h / -15 - 60 °C 2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere 3.1: hydroxylamine hydrochloride; potassium hydroxide / water; isopropyl alcohol / 60 °C View Scheme

1: triethylamine; trifluoroacetic anhydride / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere 2: hydroxylamine hydrochloride; potassium hydroxide / water; isopropyl alcohol / 60 °C View Scheme

1.1: potassium carbonate / 1,4-dioxane; water / 10 h / 0 - 20 °C 1.2: 0 °C 2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / -15 °C 2.2: 11 h / -15 - 60 °C 3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere 4.1: hydroxylamine hydrochloride; potassium hydroxide / water; isopropyl alcohol / 60 °C View Scheme

1: in methanol T=20°C; 2 h; 2: With xylene in methanol T=90 - 120°C; 16 h; Inert atmosphere;

1: CHCl3 / 3 h / 60 °C 2: xylene / Heating View Scheme

1: dimethyl sulfoxide / 20 °C 2: anhydrous xylene / 135 °C 3: lithium tert-butylate / N,N-dimethyl-formamide / 80 °C View Scheme