2-(1-氨基-1-甲基乙基)-N-[(4-氟苯基)甲基]-5-羟基-1-甲基-6-氧代-1,6-二氢嘧啶-4-甲酰胺合成路线 （共 2 条）
反应条件
1.1: lithium hydroxide hydrate / methoxybenzene; water / 15 h / 27 °C 1.2: pH 1 - 2 2.1: potassium formiate; formic acid / palladium 10 on activated carbon / water; methanol / 2.5 h / 50 °C 2.2: 21 h / 5 - 20 °C View Scheme
反应条件
1.1: triethylamine / methanol / 55 - 65 °C 1.2: 65 °C / Reflux 2.1: magnesium methanolate / dimethyl sulfoxide / 20 h / 65 °C 3.1: 5 Pd(II)/C(eggshell); methanesulfonic acid; hydrogen / methanol / 12 °C / 775.74 Torr / Large scale reaction 3.2: 5 - 23 °C / pH 8 View Scheme
参考文献
Organic Process Research and Development, , vol. 15, # 1 p. 73 - 83
