(R)-3-(1-氨基乙基)苯酚合成路线 （共 6 条）
反应条件
1: Et3N / CH2Cl2 / 5 h / 20 °C 2: BBr3 / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter
Patent: WO2010/136755 A1, 2010 ;
Location in patent: Page/Page column 67; 68 ;
WO 2010/136755 A1
反应条件
palladium 10 on activated carbon; hydrogen in acetic acid T=20°C; P=3102.97 Torr; 48 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Rao, Ramakrishna; Shewalkar, Mukesh Padmakar; Nandipati, Ramadevi; Yadav, Jhillu Singh; Khagga, Mukkanti; Shinde, Devanand Baburao
Synthetic Communications, 2012 , vol. 42, # 4 p. 589 - 598
反应条件
boron tribromide in dichloromethane T=-78 - 20°C;
参考文献
Wu, Yong-Jin; He, Huan; Sun, Li-Qiang; L'Heureux, Alexandre; Chen, Jie; Dextraze, Pierre; Starrett Jr., John E.; Boissard, Christopher G.; Gribkoff, Valentin K.; Natale, Joanne; Dworetzky, Steven I.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2887 - 2896
反应条件
glucose dehydrogenase; D-glucopyranose; [3H]-L-Alanine; Arthrobacter sp. CNB05-01 ω-transaminase; β-nicotinamide adenine dinucleotide; lactate dehydrogenase T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Fuchs, Michael; Koszelewski, Dominik; Tauber, Katharina; Kroutil, Wolfgang; Faber, Kurt
Chemical Communications, 2010 , vol. 46, # 30 p. 5500 - 5502
反应条件
1: titanium(IV) isopropylate / ethyl acetate / 3 h / Inert atmosphere 2: sodium tetrahydroborate / ethanol; ethyl acetate / 3 h / 0 °C / Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / acetic acid / 48 h / 20 °C / 3102.97 Torr / Inert atmosphere View Scheme
参考文献
Rao, Ramakrishna; Shewalkar, Mukesh Padmakar; Nandipati, Ramadevi; Yadav, Jhillu Singh; Khagga, Mukkanti; Shinde, Devanand Baburao
Synthetic Communications, 2012 , vol. 42, # 4 p. 589 - 598
反应条件
1: triethylamine / methanol / 6 h / 0 °C / Inert atmosphere 2: potassium carbonate / acetone / 0 °C / Inert atmosphere; Reflux 3: hydrogenchloride; water / methanol / 12 h / 20 °C / Inert atmosphere View Scheme
参考文献
Rao, Ramakrishna; Shewalkar, Mukesh Padmakar; Nandipati, Ramadevi; Yadav, Jhillu Singh; Khagga, Mukkanti; Shinde, Devanand Baburao
Synthetic Communications, 2012 , vol. 42, # 4 p. 589 - 598
