5-羟基-2-甲氧基吡啶合成路线 （共 14 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50°C; 3 h;
参考文献
Mahiout, Zahia; Lomberget, Thierry; Goncalves, Sylvie; Barret, Roland
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 8 p. 1364 - 1376
反应条件
1.1: 86 percent / K2CO3 / dimethylformamide / 3 h / 50 °C
2.1: MeLi; diisopropylamine / tetrahydrofuran / 3 h / 0 °C
2.2: 55 percent / tetrahydrofuran / 2 h / -40 °C
View Scheme
参考文献
Lomberget, Thierry; Radix, Sylvie; Barret, Roland
Synlett, 2005 , # 13 art. no. D11705ST, p. 2080 - 2082
反应条件
1.1: 100 percent / imidazole / dimethylformamide / 24 h / 20 °C
2.1: MeLi; diisopropylamine / tetrahydrofuran / 3 h / 0 °C
2.2: 64 percent / tetrahydrofuran / 2 h / -40 °C
3.1: 87 percent / TBAF / tetrahydrofuran / 2 h / 0 - 20 °C
4.1: K2CO3 / dimethylformamide / 3 h / 50 °C
View Scheme
参考文献
Lomberget, Thierry; Radix, Sylvie; Barret, Roland
Synlett, 2005 , # 13 art. no. D11705ST, p. 2080 - 2082
反应条件
1.1: 92 percent / NaH / dimethylformamide / 3 h / 20 °C
2.1: MeLi; diisopropylamine / tetrahydrofuran / 3 h / 0 °C
2.2: 62 percent / tetrahydrofuran / 2 h / -40 °C
3.1: 95 percent / aq. HCl / tetrahydrofuran / 3 h / 50 °C
View Scheme
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102145 A1, 2013 ;
