3-乙酰基-5-甲氧基吲哚合成路线 （共 10 条）
反应条件
1: isobutyramide With trichlorophosphate T=20°C; 0.5 h; 2: 5-Methoxy-1H-indole T=20 - 90°C; 18 h;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2005/111047 A1, 2005 ;
Location in patent: Page/Page column 77-78 ;
反应条件
diethylaluminium chloride in dichloromethane T=0°C; Acylation; 4.5 h;
参考文献
Okauchi; Itonaga; Minami; Owa; Kitoh; Yoshino
Organic letters, 2000 , vol. 2, # 10 p. 1485 - 1487
反应条件
potassium hydroxide in ethanol Reflux;
参考文献
Yu, Haifeng; Yu, Zhengkun
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 2929 - 2933
Angewandte Chemie, 2009 , vol. 121, p. 2973 - 2977
反应条件
[2,2']bipyridinyl; (1S)-10-camphorsulfonic acid; water; palladium diacetate T=120°C; 36 h;
参考文献
Jiang, Tao-Shan; Wang, Guan-Wu
Organic Letters, 2013 , vol. 15, # 4 p. 788 - 791
反应条件
trichlorophosphate T=20°C; Vilsmeier Reaction; 12 h; Cooling with ice;
参考文献
Ferro, Stefania; De Luca, Laura; Lo Surdo, Giuseppa; Morreale, Francesca; Christ, Frauke; Debyser, Zeger; Gitto, Rosaria; Chimirri, Alba
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2269 - 2279
反应条件
sodium hydroxide in water 2 h; Reflux;
参考文献
Venkatanarayana; Dubey, Pramod K.
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 656 - 662
反应条件
1: 85 percent / benzoquinone, lithium chloride / dichlorobis(acetonitrile)palladium(II) / tetrahydrofuran / 24 h / Ambient temperature 2: 80 percent / triethylamine / palladium(II) acetate, tri-o-tolylphosphine / acetonitrile / 20 h / 100 °C View Scheme
参考文献
Kasahara, Akira; Izumi, Taeko; Murakami, Satoshi; Yanai, Hiroshi; Takatori, Masayuki
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 3 p. 927 - 928
反应条件
1: 1.) AlCl3 / 1.) CH2Cl2, 25 deg C, 15 min, 2.) CH2Cl2, 25 deg C, 2 h 2: 90 percent / K2CO3 / methanol; H2O / 2 h / Heating View Scheme
参考文献
Ketcha, Daniel M.; Gribble, Gordon W.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5451 - 5457
反应条件
1,4-diaza-bicyclo[2.2.2]octane in DMF (N,N-dimethyl-formamide) T=100°C; 168 h;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2005/111047 A1, 2005 ;
Location in patent: Page/Page column 77; 78 ;
反应条件
tetrabutylammomium bromide; potassium carbonate in acetonitrile T=20°C; 0.5 h;
参考文献
Venkatanarayana; Dubey, Pramod K.
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 656 - 662
