1-(5-氯-1H-吲哚-3-基)乙酮合成路线 （共 8 条）
反应条件
1: 5-chloro-1H-indole; acetic anhydride With ammonium chloride in 1,2-dichloro-ethane T=20°C; 2 h; 2: acetic anhydride With aluminium trichloride in 1,2-dichloro-ethane 0.5 h; Further stages.;
参考文献
Pais, Godwin C. G.; Zhang, Xuechun; Marchand, Christophe; Neamati, Nouri; Cowansage, Kiriana; Svarovskaia, Evguenia S.; Pathak, Vinay K.; Tang, Yun; Nicklaus, Marc; Pommier, Yves; Burke Jr., Terrence R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 15 p. 3184 - 3194
反应条件
diethylaluminium chloride in dichloromethane T=0°C; 2 h;
参考文献
Barreca, Maria Letizia; Ferro, Stefania; Rao, Angela; De Luca, Laura; Zappala, Maria; Monforte, Anna-Maria; Debyser, Zeger; Witvrouw, Myriam; Chimirri, Alba
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 7084 - 7088
反应条件
trichlorophosphate T=20°C; Vilsmeier Reaction; 12 h; Cooling with ice;
参考文献
Ferro, Stefania; De Luca, Laura; Lo Surdo, Giuseppa; Morreale, Francesca; Christ, Frauke; Debyser, Zeger; Gitto, Rosaria; Chimirri, Alba
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2269 - 2279
反应条件
1.1: sodium hydroxide / ethanol / 3 h / Reflux 1.2: pH 5 / Cooling with ice 2.1: quinoline; copper / 3 h / Neat (no solvent); Reflux 3.1: acetic acid / 20 h / Reflux View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
反应条件
1.1: acetic acid / ethanol / Reflux 2.1: polyphosphoric acid / 4 h / 100 °C 3.1: sodium hydroxide / ethanol / 3 h / Reflux 3.2: pH 5 / Cooling with ice 4.1: quinoline; copper / 3 h / Neat (no solvent); Reflux 5.1: acetic acid / 20 h / Reflux View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
反应条件
1.1: hydrogenchloride / water / 2 h / 20 °C 1.2: 1 h / 5 °C 2.1: acetic acid / ethanol / Reflux 3.1: polyphosphoric acid / 4 h / 100 °C 4.1: sodium hydroxide / ethanol / 3 h / Reflux 4.2: pH 5 / Cooling with ice 5.1: quinoline; copper / 3 h / Neat (no solvent); Reflux 6.1: acetic acid / 20 h / Reflux View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
反应条件
1.1: polyphosphoric acid / 4 h / 100 °C 2.1: sodium hydroxide / ethanol / 3 h / Reflux 2.2: pH 5 / Cooling with ice 3.1: quinoline; copper / 3 h / Neat (no solvent); Reflux 4.1: acetic acid / 20 h / Reflux View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
反应条件
1: quinoline; copper / 3 h / Neat (no solvent); Reflux 2: acetic acid / 20 h / Reflux View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
