2-(3-溴苯基)-4,4-二甲基-4,5-二氢-1,3-恶唑合成路线 （共 5 条）
反应条件
thionyl chloride in dichloromethane
T=20°C; 1 h;
参考文献
Meiji Seika Kaisha, Ltd.
Patent: EP1180514 A1, 2002 ;
Location in patent: Example 78 ;
反应条件
potassium hydroxide in thionyl chloride; dichloromethane; water
参考文献
Shchepinov, Mikhail Sergeevich; Southern, Edwin Mellor
Patent: US2003/175742 A1, 2003 ;
反应条件
1: 96 percent / CH2Cl2 / 24 h / 20 °C
2: 58 percent / thionyl chloride / toluene; CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Houlihan, William J.; Boja, John W.; Kopajtic, Theresa A.; Kuhar, Michael J.; Degrado, Sylvia J.; Toledo, Leonel
Medicinal Chemistry Research, 1998 , vol. 8, # 1-2 p. 77 - 90
反应条件
1: SOCl2
3: SOCl2
4: 80percent NaOH
View Scheme
参考文献
Martin, Richard; Bryan Jones, J.
Tetrahedron Letters, 1995 , vol. 36, # 46 p. 8399 - 8402
反应条件
(i) SOCl2, (ii) /BRN= 505979/, CH2Cl2, (iii) SOCl2; Multistep reaction;
参考文献
Meyers,A.I. et al.
Journal of Organic Chemistry, 1974 , vol. 39, p. 2787 - 2793
