N-Boc-1,6-己二胺合成路线 （共 26 条）
反应条件
1-methylimidazolium tetrafluoroborate T=30 - 35°C; 0.0333333 h;
参考文献
Xie, Nan; Feng, Ke; Chen, Bin; Zhao, Ming; Peng, Shiqi; Zhang, Li-Ping; Tung, Chen-Ho; Wu, Li-Zhu
Journal of Materials Chemistry B, 2014 , vol. 2, # 5 p. 502 - 510
反应条件
hydrogen; palladium on activated charcoal T=20°C; P=3102.97 Torr; 1 h;
参考文献
AUCKLAND UNISERVICES LIMITED; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Patent: WO2004/26846 A1, 2004 ;
Location in patent: Page 54 ;
参考文献
Pittelkow, Michael; Lewinsky, Rasmus; Christensen, Jorn Bolstad
Synthesis, 2002 , # 15 p. 2195 - 2202
反应条件
ammonia; hydrogen; nickel in ethanol T=50°C; P=15514.4 Torr; 8 h;
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
反应条件
hydrogenchloride; sodium hydroxide in ethanol; water
参考文献
SmithKline Beecham Corporation
Patent: US6403578 B1, 2002 ;
反应条件
triethylamine in chloroform; acetone
参考文献
Associated Universities, Inc.
Patent: US5021571 A1, 1991 ;
反应条件
ammonium hydroxide in methanol 48 h;
参考文献
Fixon-Owoo, Solomon; Levasseur, Frederic; Williams, Keith; Sabado, Thomas N.; Lowe, Mike; Klose, Markus; Mercier, A. Joffre; Fields, Paul; Atkinson, Jeffrey
Phytochemistry, 2003 , vol. 63, # 3 p. 315 - 334
反应条件
1: 98 percent / 1N aq. NaOH / dioxane / 0 deg C to room temp., 2: 1.) Et3N, ethyl carbonochloridate, 2.) 20percent aq. NH3 / 1.) THF, -10 deg C, 20 min., 2.) -10 deg C to room temp., overnight 3: 75 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., 4: 63 percent / NH3, H2 / Raney Ni / ethanol / 8 h / 50 °C / 15514.4 Torr View Scheme
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
反应条件
1: 1.) Et3N, ethyl carbonochloridate, 2.) 20percent aq. NH3 / 1.) THF, -10 deg C, 20 min., 2.) -10 deg C to room temp., overnight 2: 75 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., 3: 63 percent / NH3, H2 / Raney Ni / ethanol / 8 h / 50 °C / 15514.4 Torr View Scheme
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
反应条件
1: 75 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., 2: 63 percent / NH3, H2 / Raney Ni / ethanol / 8 h / 50 °C / 15514.4 Torr View Scheme
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
