N-Boc-1,6-己二胺合成路线 （共 26 条）
反应条件
1: 98 percent / 1N aq. NaOH / dioxane / 0 deg C to room temp., 2: 1.) Et3N, ethyl carbonochloridate, 2.) 20percent aq. NH3 / 1.) THF, -10 deg C, 20 min., 2.) -10 deg C to room temp., overnight 3: 75 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., 4: 63 percent / NH3, H2 / Raney Ni / ethanol / 8 h / 50 °C / 15514.4 Torr View Scheme
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
反应条件
in 1,4-dioxane 22 h;
参考文献
Suryakiran; Prabhakar; Reddy, T. Srikanth; Rajesh; Venkateswarlu
Tetrahedron Letters, 2006 , vol. 47, # 46 p. 8039 - 8042
反应条件
1: dimethylsulfoxide; diethyl ether / 2 h / Ambient temperature 2: aq. NaOH View Scheme
参考文献
Dredar, Sasi A.; Blankenship, James W.; Marchant, Pamela E.; Manneh, Victor; Fries, David S.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 984 - 989
反应条件
1: dimethylsulfoxide; diethyl ether / 2 h / Ambient temperature 2: aq. NaOH View Scheme
参考文献
Hansen, John B.; Langvad, Eyvind; Frandsen, Flemming; Buchardt, Ole
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1510 - 1514
反应条件
1: 99 percent / tetrahydrofuran / 20 °C 2: 75 percent / aq. NH4OH / methanol / 48 h View Scheme
参考文献
Fixon-Owoo, Solomon; Levasseur, Frederic; Williams, Keith; Sabado, Thomas N.; Lowe, Mike; Klose, Markus; Mercier, A. Joffre; Fields, Paul; Atkinson, Jeffrey
Phytochemistry, 2003 , vol. 63, # 3 p. 315 - 334
参考文献
Hansen, John B.; Langvad, Eyvind; Frandsen, Flemming; Buchardt, Ole
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1510 - 1514
反应条件
in diethyl ether; dimethyl sulfoxide 1 h; Ambient temperature;
参考文献
Hansen, J. B.; Nielsen, M. C.; Ehrbar, U.; Buchardt, O.
Synthesis, 1982 , # 5 p. 404 - 405
反应条件
in chloroform T=20°C;
参考文献
Nguyen, Trung Xuan; Morrell, Andrew; Conda-Sheridan, Martin; Marchand, Christophe; Agama, Keli; Bermingam, Alun; Stephen, Andrew G.; Chergui, Adel; Naumova, Alena; Fisher, Robert; O'Keefe, Barry R.; Pommier, Yves; Cushman, Mark
Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4457 - 4478
参考文献
Stahl,G.L. et al.
Journal of Organic Chemistry, 1978 , vol. 43, # 11 p. 2285 - 2286
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; Condensation; 24 h;
参考文献
Kossanyi, Alain; Mestre, Beatrice; Perree-Fauvet, Martine
Synthetic Communications, 1999 , vol. 29, # 24 p. 4341 - 4346
